Trial | NCT04382768  Report issue

Title

Inhaled Ibuprofen to Treat COVID-19
Extended Compassionate Use Program (UCA) With Inhalational Ibuprofen in Patients With Acute Respiratory Pathology, Mediated by COVID-19.

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    40
The study aims to evaluate the reduction in severity and progression of lung injury with inhaled ibuprofen in patients with severe acute respiratory syndrome due to SARS-CoV-2 virus.
Study Started
May 01
2020
Primary Completion
Jan 31
2021
Anticipated
Study Completion
Jan 31
2021
Anticipated
Last Update
Jun 11
2020

Drug Inhaled Hypertonic ibuprofen

Standard of care plus lipid ibuprofen 50mg tid

Luarprofen Experimental

Inhaled Hypertonic ibuprofen 50 mg tid

Criteria 

Inclusion Criteria:

Provision of written informed consent by the patient OR by the patient's Legal Representative.
Confirmed or suspected SARS-CoV-2 infection;
Pneumonia without criteria of severity.

With some of the following conditions:

Diabetes.
Cardiovascular disease.
Chronic kidney disease.
Chronic obstructive pulmonary disease.
Structural diseases of the lung
Immunocompromise.
Patient who presents negative results by rtPCR for SARS CoV-2, in case of being highly suspicious, the patient may receive it empirically until the results are obtained.
No unstable bronchial asthma

Exclusion Criteria:

The doctor considers that participation in the Program is not the best for patients or for any condition that prevents the Program from being followed safely.
Patients with a history of unstable bronchial asthma
The patient is allergic to ibuprofen or any of the compounds in the preparation.
Hypersensitivity to the drug, nasal polyps syndrome, angioedema or bronchospasm against aspirin or other NSAIDs.
Pregnant or lactating woman, or positive pregnancy test on a pre-dose exam.
Patient who is expected to be transferred to another place other than the place where the Program starts, within 7 days of starting it.
No Results Posted