Trial | NCT04316390  Report issue

Official Title

Influence of Hesperidin and Vitamin C on Uric Acid Concentration

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    40
Aim of the study is to investigate the impact of hesperidin and/or vitamin C on elevated uric acid concentrations.
Duration of the study is 9 weeks. 1) a washout week, 2) two intervention weeks, 3) four weeks washout period, 4) two intervention weeks.

The study is conducted under free living conditions. During washout weeks consumption of orange juice or citrus fruits or vitamin C containing supplements is restricted.

During intervention weeks 200 mL of study drink is consumed daily. And participants are asked to maintain their normal physical activity and habitual diet. Additional citrus or vitamin C containing beverages are not allowed.

At the beginning and the end of each intervention phase uric acid, insulin sensitivity, blood pressure, pulse wave velocity and bioavailability of hesperidin are assessed.
Study Started
Jul 15
2022
Primary Completion
Mar 22
2023
Study Completion
Mar 30
2023
Last Update
Jul 03
2023

Dietary Supplement Control

study drink (two weeks)

Dietary Supplement Hesperidin

study drink + Hesperidin 600 mg (two weeks)

Dietary Supplement Vitamin C

study drink + Vitamin C 250 mg (two weeks)

Dietary Supplement Hesperidin + Vitamin C [hesperidin, vitamin c]

study drink + Hesperidin 600 mg + Vitamin C 250 mg (two weeks)

Hesperidin (A) Experimental

study drink without hesperidin and without vitamin C compared to study drink with hesperidin

Hesperidin + Vitamin C (B) Experimental

study drink with vitamin C compared to study drink with hesperidin and vitamin C

Criteria 

Inclusion Criteria:

healthy
higher uric acid concentration (≥5.5 mg/dL)
Informed written consent

Exclusion Criteria:

pregnancy
fructose intolerance
smoking
gout or medicated hyperuricemia
diabetes mellitus
antidiabetic or cytostatic medication
weight loss (≥5% in the past 3 months)
consumption of vitamin C-containing supplements
parallel participation in a clinical trial
anemia and / or iron deficiency
No Results Posted