Trial | NCT04297176  Report issue

Title

Economic Evaluation of Vancomycin Therapeutic Drug Monitoring Methods
Clinical and Economic Evaluation of Optimal Monitoring Parameters and Sampling Schemes for Vancomycin Therapeutic Drug Monitoring in Qatar

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    65
Vancomycin is a widely used antibiotic in the treatment of complicated gram positive infections. Approaches to vancomycin therapeutic drug monitioring (TDM) vary. This clinical trial aimed to compare the pharmacoeconomic outcomes between various vancomyicn TDM approaches.

Research questions: Which vancomycin therapeutic drug monitoring (TDM) approach is associated with superior economic outcomes?

-Objectives: In this proposed multicenter randomized controlled trial (RCT), we aim to compare the pharmacoeconomic outcomes of various vancomycin TDM approaches.
Study Started
Jan 23
2020
Primary Completion
May 04
2021
Study Completion
Jul 02
2021
Last Update
Aug 15
2022

Drug Vancomycin-traditional dosing

The dose is calculated based on 2 vancomycin serum levels

Drug Vancomycin- Trough-only based dosing

The dose is calculated based on 1 vancomycin serum level (i.e. trough)

Traditional monitoring method Experimental

Patients are dosed using two timed vancomycin serum concentrations

One concentration method Active Comparator

Patients are dosed based on one timed vancomycin serum level

Criteria 

Inclusion Criteria:

adults at least 18 yrs who are hospitalized and initiated on IV vancomycin

Exclusion Criteria:

renal instability
immunosuppression;
vancomycin allergy;
history of recurrent peritonitis
administration of < 4 doses of vancomycin
pregnancy;
hemoglobin < 8 g/dL.
No Results Posted