Title
Vitamin C to Reduce Vasopressor Dose in Septic Shock
Vitamin C to Reduce Exogenous Vasopressor Dose in Septic Shock; a Randomized Clinical Trial
Phase
Phase 3Lead Sponsor
Hospital Español de MexicoStudy Type
InterventionalStatus
Unknown statusIndication/Condition
Septic Shock SepsisIntervention/Treatment
Vitamin C ...Study Participants
180Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included.
Patients will be randomized to one of the study groups:
Intervention Group: Vitamin C 6 grams in 250 ml of 0.9% saline solution every 24 hours, in continuous infusion for 72 hours.
Placebo Group: 0.9% saline solution 250 ml every 24 hours, in continuous infusion for 72 hours.
Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included.
Patients will be randomized to one of the study groups:
Intervention Group: Vitamin C 6 grams in 250 ml of 0.9% saline solution every 24 hours, in continuous infusion for 72 hours.
Placebo Group: 0.9% saline solution 250 ml every 24 hours, in continuous infusion for 72 hours.
Bottles will be identical, only identified by the sequential number of the patient that has been included.
Primary objective is to demonstrate that the administration of intravenous Vitamin C decreases the dose of exogenous vasopressors in patients with septic shock
6 grams of Vitamin C in 250 ml of 0.9% saline in continuous infusion for 24 hours, 3 doses.
Placebos: 250 ml of 0.9% saline in continuous infusion for 24 hours, 3 doses.
Inclusion Criteria: Adults Septic Shock Exclusion Criteria: Previous treatment exceeded 24 hours Refusal to participate Do Not Resuscitate Participation in another trial
