Trial | NCT03700541  Report issue

Title

Influence of Opioid Analgesia on Circulating Tumor Cells in Laparoscopic Colorectal Cancer Surgery
Influence of Peri-operative Opioid Analgesia on Circulating Tumor Cells in Patients Undergoing Laparoscopic Colorectal Cancer Surgery - Multi-center, Randomized Clinical Trial

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    71
To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery. To find correlations with other perioperative factors and clinical/pathological disease characteristics.
Study Started
Jan 07
2019
Primary Completion
Nov 01
2023
Study Completion
Dec 06
2023
Last Update
Dec 07
2023

Drug Morphine

Morphine intravenous

Drug Piritramid

Piritramid intravenous

Morphine Active Comparator

Morphine-based perioperative analgesia

Piritramid Active Comparator

Piritramid-based perioperative analgesia

Criteria 

Inclusion Criteria:

patients undergoing open radical surgery for colorectal cancer
age over 18 years
signed informed consent

Exclusion Criteria:

intolerance of the study drugs
history of CRC surgery
neoadjuvant therapy
other malignancy not in permanent remission
chronic opioid medication or opioid administration within 7 days preoperatively
immunosuppressive or corticosteroid therapy
surgery within 30 days preoperatively (except minor)
chronic or acute infection
No Results Posted