Active Ingredient History
Piritramide(R-3365, trade names Dipidolor, Piridolan, Pirium and others) is a synthetic opioid analgesic that is marketed in certain European countries including: Austria, Belgium, Czech Republic, Slovenia, Germany and the Netherlands. It comes in free form, is about 0.75x times as potent as morphine and is given parenterally for the treatment of severe pain. Nausea, vomiting, respiratory depression and constipation are believed to be less frequent with piritramide than with morphine, and it produces more rapid-onset analgesia when compared to morphine and pethidine. After intravenous administration the onset of analgesia is as little as 1–2 minutes, which may be related to its great lipophilicity. The analgesic and sedative effects of piritramide are believed to be potentiated with phenothiazines and its emetic (nausea/vomiting-inducing) effects are suppressed. The volume of distribution is 0.7-1 L/kg after a single dose, 4.7-6 L/kg after steady-state concentrations are achieved and up to 11.1 L/kg after prolonged dosing. Wikipedia
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Bone Marrow Cells (Phase 4)
Colonic Neoplasms (Phase 4)
Colorectal Neoplasms (Phase 4)
General Surgery (Phase 3)
Neoplasm, Residual (Phase 4)
Neoplastic Cells, Circulating (Phase 4)
Pain (Phase 4)
Pain, Postoperative (Phase 4)
Postoperative Nausea and Vomiting (Phase 4)
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