Trial | NCT03463642  Report issue

Title

The Efficacy of Different Vitamin D Supplementation Delivery Methods
The Efficacy of Different Vitamin D Supplementation Delivery Methods on Serum 25(OH)D in Humans a Randomised Double-blind Placebo Trial

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    62
To test the efficacy of different vitamin D delivery methods on serum 25(OH)D. Participants randomly assigned to one of seven groups - three placebo groups and 4 active supplement groups receiving 100,000IU vitamin D3
Various delivery methods of vitamin D supplementation are available to consumers but there have been no studies providing evidence of whether one delivery method is superior to others. The researchers wanted to compare the delivery of 100,000IU vitamin D3 by three methods on serum 25(OH)D levels. Two methods of oral supplementation (pill [prolonged release] and liquid [immediate release]), and delivery through the skin (with and without a penetrator enhancer. Placebo groups were pill, oral liquid and skin applied oil
Study Started
Feb 02
2017
Primary Completion
Apr 04
2017
Study Completion
Apr 04
2017
Last Update
Mar 14
2018

Dietary Supplement vitamin D3

100,000IU

Dietary Supplement Pill

Dicalcium phosphate, microcrystalline cellulose, silicium dioxide, magnesium stearate

Dietary Supplement orange syrup

100 drops orange syrup

Other mineral oil

Paraffinum Liquidum,Isopropyl Palmitate,Parfum

Dietary Supplement Penetrator

Tangerine essential oil (10ml)

Vitamin D3 pill Experimental

100 pills = 100,000IU + Dicalcium phosphate, microcrystalline cellulose, silicium dioxide, magnesium stearate

Pill placebo Placebo Comparator

100 pills = Dicalcium phosphate, microcrystalline cellulose, silicium dioxide, magnesium stearate

  • Dietary Supplement Pill

Vitamin D3 oral liquid Experimental

100 drops = 100,000IU in orange syrup

Oral liquid placebo Placebo Comparator

100 drops orange syrup

Skin oil + Vitamin D3 + penetrator Experimental

100,000IU + mineral oil+ Tangerine essential oil (10ml)

Skin oil + Vitamin D3 Experimental

100,000IU + mineral oil

Skin oil placebo Placebo Comparator

Skin application: 100ml of mineral oil coloured with food colourant to match active oil sample

Criteria 

Inclusion Criteria:

healthy, female

Exclusion Criteria:

any participant that was taking vitamin supplementation, had a skin condition that would prevent them from applying oil to their skin or were taking, or had been taking in the past 6-months, oestrogen based contraception
No Results Posted