Title
Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis
Randomized, Controlled, Multicenter Studies of the Effects of Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis
Phase
Phase 4Lead Sponsor
Chinese Academy of Medical SciencesStudy Type
InterventionalStatus
Unknown statusIndication/Condition
Pancreatitis, Acute HypertriglyceridemiaIntervention/Treatment
Insulin ...Study Participants
220To investigate an economical and effective way to reduce the level of serum triglyceride in patients with hypertriglyceridemia-induced acute pancreatitis.
Insulin infusion for subjects in Group Insulin.
Aphesis for subjects in Group Aphesis.
Inclusion Criteria: Adult aged 18 to 80 years old; abdominal pain consistent with AP; serum amylase and / or lipase activity is at least 3 times higher than the normal upper limit; abdominal imaging consistent with AP imaging changes. severe hyperlipidemia "fasting serum TG> 1,000 mg/dL (11.2mmol/L)"; except for other AP causes, such as cholelithiasis, alcohol, drugs and so on. Exclusion Criteria: other etiologies other than hyperlipidemia leading to AP; fasting serum TG less than 1,000 mg / dL (11.2mmol / L); acute lipid-induced pancreatitis at the same time combined with other etiologies of acute pancreatitis. the existence of plasma replacement contraindications: serious allergies to plasma, human serum albumin, heparin and others; the existence of mental disorders; unstable heart or cerebral infarction; intracranial hemorrhage or severe cerebral edema associated with hernia. without informed consent, the patient refused to plasma replacement, and other circumstances may bring significant bias.
