Trial | NCT02923336  Report issue

Title

Evaluation of Gastrointestinal Transit Pre and Pos Treatment With Non Selective Betablocker in a Population of Cirrhotics
Evaluation of Gastrointestinal Transite in Cirrhotic Patient Pre and Post Treatment With Non Selective Betablockers (Propanolol)

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Unknown status

  • Intervention/Treatment

    propranolol ...

  • Study Participants

    10
The purpose of this study is to evaluate the influence of non betablockers in gastrointestinal motility (transit time) in patients with liver cirrhosis.
There is some evidence that cirrhotic patients have increased gastrointestinal transit time, this issue may favor bacterial owergrowth, and consequently bacterial translocation. Translocation of bacterias and its products are linked to vascular and hemodynamics alterations that produce descompensation on the disease. There is evidence , in animal models , that the use of beta blockers favors the gastrointestinal movement; decompensated cirrhotics had significantly longer small bowel transit time as compared with compensated cirrhotics, there have described that this alteration is related to de cirrhosis severity as assessed by Child Pugh score. The purpose of this study is to evaluate the gastrointestinal transit time before and after treatment of non selective betablockers, we are going to evaluate the gastrointestinal time before and after of 4 weeks of non selectivebetablocker treatment, in decompensated cirrhotics. The gastrointestinal time is going to be evaluate by the ingestion of a device known as "smart pill", that allow ambulatory monitoring of gastrointestinal transit.
Study Started
May 31
2015
Primary Completion
Jan 31
2019
Study Completion
May 31
2021
Anticipated
Last Update
Jan 31
2019

Drug non selective beta blocker

the patient is going to receive a device called "smart pill" before the beginning of treatment with propranolol, after the evaluation with the smart pill device, they are goning to take propranolol (dose of propranolol 80 mg per day) for 4 weeks,finally they will receive another smart pill to evaluate the second gastrointestinal transit time

  • Other names: propranolol

Smart pill Other

Single group, before and after, the same group is going to be its own control

Criteria 

Inclusion Criteria:

Cirrhosis of any ethiology
Child Pugh A, B, C without beta-blocker treatment previously (min. 1 month without treatment)
Patients with previous variceal bleeding (with liver cirrhosis) * Patients with ascites or bacterial spontaneous peritonitis

Exclusion Criteria:

Variceal disease without cirrhosis
Cirrhotics patients that use antibiotics, prebiotics and probiotics during the study period and one month previously
Patients under immunosuppressor treatment
Patients with portal thrombosis
Patients with Sd. Budd-Chiari or cava/suprahepatic thrombosis
Patients with active infection process
No Results Posted