Trial | NCT02785653  Report issue

Title

Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium
Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium Under Routine Clinical Practice

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    60
This study evaluates the potentiation of muscle relaxation caused by rocuronium by inhalational agent sevoflurane. Half the patients will be ventilated with oxygen ,nitrous oxide and sevoflurane during induction of anaesthesia and half will be ventilated only with oxygen and nitrous oxide.
Rocuronium is a non depolarizing muscle relaxant. Inhalational general anaesthetic agents like Sevoflurane have some muscle relaxation effect by depressing the spinal motor neurons. Inhalational anaesthetics also alter the tonic input received from descending modulatory systems from the brain. Deep anaesthesia with inhalational agents may cause some degree of neuromuscular blockade.
Study Started
Apr 30
2004
Primary Completion
Nov 30
2006
Study Completion
Nov 30
2006
Last Update
Jun 09
2016
Estimate

Drug Sevoflurane

Patients were ventilated with 2 % inspired concentration of sevoflurane in a fresh gas flow of 5 litres containing 66.6% nitrous oxide and 33.3% percent of oxygen

  • Other names: Sevorane

Drug Rocuronium

rocuronium 0.6mg per kg body weight was given intravenously after induction of anaesthesia

  • Other names: Esmeron

sevoflurane and rocuronium Experimental

After induction of general anaesthesia, patients in the sevoflurane group were ventilated with fresh gas flow of 5 lites per minute consisting of 66.6% nitrous oxide and 33.3% oxygen with 2% inspired concentration of sevoflurane. After stabilization of end tidal carbondioxide to 30-35 mmHg ,intravenous rocuronium 0.6mg per Kg body weight was injected

rocuronium Active Comparator

After induction of general anaesthesia, patients in the control group were ventilated with fresh gas flow of 5 lites per minute consisting of 66.6% nitrous oxide and 33.3% oxygen . After stabilization of end tidal carbondioxide to 30-35 mmHg ,intravenous rocuronium 0.6mg per Kg body weight was injected

Criteria 

Inclusion Criteria:

American society of anaesthesiologists physical status 1 and 2
Age between 18-65
Mallampatti classification 1 and 2

Exclusion Criteria:

Patients refusal to participate
American society of anaesthesiologists physical status 3 and 4
Mallampatti classification 3 and 4
Patients with neuromuscular disorder
Patients on medications that affect neuromuscular block
Pregnant and lactating patients
No Results Posted