Active Ingredient History
Sevoflurane is a general anesthetic that is FDA approved for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery. Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase and also binds to the GABA receptor. Common adverse reactions include cardiovascular: bradyarrhythmia, hypotension, gastrointestinal: nausea, vomiting, neurologic: somnolence, psychiatric: agitation, respiratory: cough, interrupted breathing and other: shivering. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Anesthesia, General (approved 1995)
Abdominal Neoplasms (Phase 4)
Acne Vulgaris (Phase 4)
Acute Kidney Injury (Phase 4)
Acute Pain (Phase 4)
Aged (Phase 4)
Airway Management (Phase 4)
Alcohol Amnestic Disorder (Phase 4)
Alcohol-Related Disorders (Phase 2)
Allergy and Immunology (Phase 3)
Ambulatory Surgical Procedures (Phase 4)
Amnesia (Phase 1)
Analgesia (Phase 3)
Analgesics (Phase 3)
Analgesics, Opioid (Phase 4)
Anesthesia (Phase 4)
Anesthesia and Analgesia (Phase 4)
Anesthesia, Conduction (Phase 4)
Anesthesia, Endotracheal (Phase 4)
Anesthesia, General (Phase 4)
Anesthesia, Inhalation (Phase 4)
Anesthesia, Intravenous (Phase 4)
Anesthesia, Local (Phase 3)
Anesthesia, Spinal (Phase 4)
Anesthetics (Phase 4)
Anesthetics, Inhalation (Phase 3)
Aneurysm (Phase 4)
Anxiety (Phase 4)
Aortic Diseases (Phase 4)
Aortic Valve Insufficiency (Phase 3)
Arthritis (Phase 4)
Atrial Fibrillation (Phase 1/Phase 2)
Back Pain (Phase 3)
Balanitis (Phase 2)
Bariatric Surgery (Phase 4)
Behavior (Phase 4)
Blood Loss, Surgical (Phase 4)
Brain Injuries (Phase 4)
Brain Neoplasms (Phase 4)
Breast Neoplasms (Phase 4)
Calculi (Phase 4)
Carcinoma (Phase 4)
Carcinoma, Hepatocellular (Phase 4)
Carcinoma, Non-Small-Cell Lung (Phase 3)
Cardiovascular Diseases (Phase 4)
Carotid Artery Diseases (Early Phase 1)
Carotid Stenosis (Phase 4)
Cerebral Arterial Diseases (Phase 3)
Cesarean Section (Phase 4)
Child Development (Phase 3)
Cholangiocarcinoma (Phase 4)
Chronic Pain (Phase 4)
Cognition Disorders (Phase 4)
Cognitive Aging (Phase 4)
Cognitive Dysfunction (Phase 4)
Colonic Neoplasms (Phase 4)
Colorectal Neoplasms (Phase 4)
Colorectal Surgery (Phase 3)
Consciousness (Phase 4)
Conscious Sedation (Phase 4)
Coronary Artery Bypass (Phase 4)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 4)
Coronavirus (Phase 3)
Cough (Phase 4)
COVID-19 (Phase 4)
Craniofacial Abnormalities (Phase 2)
Craniotomy (Phase 3)
Cryptorchidism (Phase 4)
Cystoscopes (Phase 3)
Delayed Emergence from Anesthesia (Phase 4)
Delirium (Phase 4)
Dementia (Phase 4)
Dental Anxiety (Phase 2)
Depression (Phase 4)
Depressive Disorder (Phase 4)
Dexmedetomidine (Phase 3)
Disease Progression (Phase 4)
Down Syndrome (Phase 2)
Drug Interactions (Phase 4)
Drug Misuse (Phase 4)
Drugs, Generic (Phase 4)
Drugs, Investigational (Phase 4)
Eating (Phase 4)
Electroconvulsive Therapy (Phase 4)
Emergence Delirium (Phase 4)
Energy Metabolism (Phase 4)
Epigenomics (Phase 4)
Epilepsy (Phase 4)
Esophageal Neoplasms (Phase 3)
Etomidate (Phase 4)
Evoked Potentials, Motor (Phase 4)
Extracorporeal Membrane Oxygenation (Phase 2)
Fluoride Poisoning (Phase 3)
France (Phase 2)
Funnel Chest (Phase 4)
Gabapentin (Phase 3)
Gallbladder Neoplasms (Phase 4)
General Surgery (Phase 4)
Genital Diseases, Female (Phase 4)
Geriatrics (Phase 4)
Glycogen Synthase Kinase 3 (Phase 4)
Gynecology (Phase 4)
Headache (Phase 4)
Healthy Volunteers (Phase 4)
Heart Arrest (Phase 4)
Heart Defects, Congenital (Phase 4)
Heart Diseases (Phase 4)
Heart Valve Diseases (Phase 4)
Hemodynamics (Phase 4)
Hemorrhage (Phase 2)
Hernia (Phase 4)
Hernia, Inguinal (Phase 4)
Hip Fractures (Phase 4)
Hydrocephalus (Phase 4)
Hyperalgesia (Phase 4)
Hypertension (Phase 4)
Hypnotics and Sedatives (Phase 4)
Hypotension (Phase 4)
Hypoventilation (Phase 4)
Hypoxia, Brain (Phase 4)
Hysteroscopy (Phase 4)
Infant, Newborn (Phase 2/Phase 3)
Infections (Phase 4)
Inflammation (Phase 1)
Informed Consent (Phase 2)
Inhalation (Phase 4)
Intensive Care Units, Pediatric (Phase 3)
Intracranial Aneurysm (Phase 4)
Intraoperative Awareness (Phase 4)
Intubation (Phase 4)
Intubation, Intratracheal (Phase 3)
Ketamine (Phase 3)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 3)
Kidney Neoplasms (Phase 4)
Kidney Transplantation (Phase 3)
Laparoscopy (Phase 4)
Laryngeal Masks (Phase 4)
Laryngismus (Phase 4)
Lasers (Phase 4)
Leg Ulcer (Phase 4)
Lidocaine (Phase 3)
Liver Diseases (Phase 3)
Liver Neoplasms (Phase 4)
Liver Transplantation (Phase 4)
Lung (Phase 4)
Lung Diseases (Phase 4)
Lung Neoplasms (Phase 4)
Lung Transplantation (Phase 4)
Lymphoma (Phase 2/Phase 3)
Magnetic Resonance Spectroscopy (Phase 4)
Malocclusion, Angle Class III (Phase 4)
Mandibular Diseases (Phase 4)
Mastectomy, Radical (Phase 1/Phase 2)
Melanoma (Phase 4)
Memory Disorders (Phase 4)
Microcirculation (Phase 4)
Middle Aged (Phase 4)
Mitral Valve Insufficiency (Phase 3)
Muscle Relaxants, Central (Phase 4)
Muscle Relaxation (Phase 4)
Musculoskeletal Diseases (Phase 3)
Myocardial Infarction (Phase 4)
Myocardial Reperfusion Injury (Phase 4)
Myocardium (Phase 4)
Narcotics (Phase 3)
Nausea (Phase 4)
Neoplasms (Phase 4)
Nerve Block (Phase 4)
Neurocognitive Disorders (Phase 4)
Neurodevelopmental Disorders (Phase 3)
Neurofibromatoses (Phase 4)
Neuromuscular Blockade (Phase 4)
Neuromuscular Junction Diseases (Phase 3)
Neurosurgery (Phase 3)
Nitrous Oxide (Phase 4)
Nociceptive Pain (Phase 4)
Obesity (Phase 4)
Obesity, Morbid (Phase 4)
Opioid-Related Disorders (Phase 2)
Osteoarthritis (Phase 4)
Ovarian Neoplasms (Phase 4)
Oxidative Stress (Phase 4)
Oximetry (Phase 3)
Oxygen Saturation (Phase 4)
Pain (Phase 4)
Pain Measurement (Phase 2/Phase 3)
Pain, Postoperative (Phase 4)
Palonosetron (Phase 4)
Paraphimosis (Phase 2)
Pathologic Processes (Phase 3)
Pediatrics (Phase 4)
Perioperative Care (Phase 4)
Pharmacokinetics (Phase 4)
Phimosis (Phase 2)
Pituitary Neoplasms (Phase 4)
Poisoning (Phase 3)
Postoperative Cognitive Complications (Phase 4)
Postoperative Complications (Phase 4)
Postoperative Nausea and Vomiting (Phase 4)
Propofol (Phase 4)
Prostatic Neoplasms (Phase 4)
Rectal Neoplasms (Phase 4)
Renal Insufficiency (Phase 4)
Reperfusion Injury (Phase 4)
Respiratory Aspiration (Phase 4)
Respiratory Distress Syndrome (Phase 4)
Respiratory Insufficiency (Phase 3)
Respiratory System Abnormalities (Phase 4)
Retinal Diseases (Phase 4)
Rotator Cuff Injuries (Phase 4)
Sclerosis (Phase 4)
Severe Acute Respiratory Syndrome (Phase 4)
Sevoflurane (Phase 4)
Shock, Septic (Phase 2)
Sinusitis (Phase 4)
Sleep Apnea, Obstructive (Phase 4)
Sleep Apnea Syndromes (Phase 4)
Spinal Cord Diseases (Phase 4)
Spinal Diseases (Phase 4)
Spinal Fusion (Phase 3)
Spinal Injuries (Phase 4)
Substance-Related Disorders (Phase 2)
Surgical Oncology (Phase 4)
Surgical Procedures, Operative (Phase 4)
Survival (Phase 4)
Thoracic Surgery (Phase 4)
Tonsillectomy (Phase 4)
Tonsillitis (Phase 2)
Unconsciousness (Phase 4)
Ureteral Diseases (Phase 4)
Urinary Bladder Diseases (Phase 4)
Uterus (Phase 4)
Vaginal Diseases (Phase 4)
Vascular Diseases (Phase 4)
Vascular Surgical Procedures (Phase 4)
Ventricular Dysfunction (Phase 4)
Xenon (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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