Trial | NCT02778958  Report issue

Title

Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery
Comparisons of iv Ibuprofen and iv Paracetamol for Postoperative Pain Levels and Opioid Consumption During Bariatric Surgery

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    40
The aim of this study is to evaluate and to compare the effectiveness of iv ibuprofen and iv paracetamol during bariatric surgery.
Evaluation of effectiveness of iv ibuprofen and iv paracetamol on postoperative pain, opioid consumption, and side effects in morbidly obese patients undergoing bariatric laparoscopic surgery
Study Started
Jan 31
2016
Primary Completion
Jan 31
2017
Study Completion
Mar 31
2017
Last Update
Mar 14
2018

Drug paracetamol

iv paracetamol flakon, 1 gram infusion at 30 min; iv morphine with patient controlled analgesia (1 mg demand bolus dose, 20 min lockout time)

  • Other names: Acetaminophen

Drug ibuprofen

iv ibuprofen flakon, 800 mg; iv morphine with patient controlled analgesia (1 mg demand bolus dose, 20 min lockout time)

  • Other names: İntrafen

ibuprofen and morphine Experimental

iv ibuprofen 800 mg infusion at 30 min before skin incision closed and per 6 hours during postoperative period; iv morphine with patient controlled analgesia (1 mg demand bolus dose, 20 min lockout time)

paracetamol and morphine Active Comparator

iv paracetamol 1 gram infusion at 30 min before skin incision closed and per 6 hours during postoperative period; iv morphine with patient controlled analgesia (1 mg demand bolus dose, 20 min lockout time)

Criteria 

Inclusion Criteria:

Patients undergoing laparoscopic sleeve gastrectomy and gastric by-pass surgery

Exclusion Criteria:

Hepatic disfunction,
Renal failure (creatinine > 3 mg/dL,creatinin clearance < 60 mL/dk or urine out-put < 500 mL/day ) or a history of dialysis 28 days before surgery,
A history of gastrointestinal bleeding or bleeding diathesis 6 weeks before surgery, therapeutic dose of anticoagulation therapy (except subcutaneous heparin prophylactic dose),
Angiotensin converting enzymes inhibitor or antihypertensive combination with furosemide,
A history of opioid addiction or opioid tolerance
Allergy to study drugs,
Noncooperative patients for pain assessments
No Results Posted