Title
Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic Syndrome
Phase 1-2 Study of Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic Syndrome
Phase
Phase 1/Phase 2Lead Sponsor
Republican Scientific Center for Emergency MedicineStudy Type
InterventionalStatus
Completed Results PostedIndication/Condition
Metabolic SyndromeIntervention/Treatment
orlistat diltiazem atorvastatin pioglitazone lisinopril ...Study Participants
351Metabolic syndrome: aetiology, pathogenesis, diagnosis, clinical management and prognosis
Purpose: To create the complex scientifically proved concept of Metabolic syndrome (МS) development based on elaboration of the new methods of clinical diagnostics of МS components and highly effective МS clinical management in comparative studying of clinical, laboratory and cost effectiveness.
Participants and methods: This clinical study included 351 adults (184 female) in the Scientific research institute of cardiology and internal diseases (Almaty, the Republic of Kazakhstan). Statistical analysis was performed using Microsoft Excel-2008 in updating Lapach, Chubenko et al (2000) and SPSS for Windows v.17.0.
Xenical (Orlistat) - 120 mg/day in integration of Pionorm (Pioglitazone hydrochlorid) - 30 mg/day, Diroton (Lizinopril) - 20 mg/day, Diltiazem - 90 mg/day, Atorvastatin (Liprimar) - 40 mg/day
Vegetable and salt diet
Xenical, Pionorm, Diroton, Diltiazem, Atorvastatin
Vegetables and salt diet
64 healthy people
Inclusion Criteria: written consent form age> 25 years skinfold thickness > 0,7 cm BP> 130/85 mm Hg or a patient on antihypertensive medications fasting blood glucose > 6.1 mmole/L, or 2-hour postprandial glucose level > 11.1 mmole/L / or a patient with type 2 diabetes blood cholesterol > 5.6 mmole/L possibility of treatment > 6 months follow-up > 1 year Exclusion Criteria: complete immobilization of a patient (paresis /paralysis) patients with severe concomitant diseases of the kidneys and (or) of the liver early post-operative condition mental illness pregnancy persons who are in prison persons who are in military Armed Forces
| Event Type | Organ System | Event Term | Conventional Patient Group | "Analimentary Detoxication" | Healthy People |
|---|
Fasting blood glucose (FBG) (mmole/L) and Two-hour postprandial glucose (THPG) (mmole/L) were measured.
Systolic and Diastolic Blood Pressures (mm Hg) was measured by manual/automatic tonometery
Blood sample for lipid profile (Cholesterol in mmole/L, High-density Lipoproteids in mmole/L, Triglycerides in mmole/L) was measured
Immunoassay Insulin in the blood (in nU/L) was investigated
Immunoassay Cortisole in the blood (nmole/L) was measured
