Active Ingredient History

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Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE). Lisinopril is marketed under the brand name ZESTRIL. ZESTRIL is indicated for the treatment of hypertension. It may be used alone as initial therapy or concomitantly with other classes of antihypertensive agents. It is also indicated as adjunctive therapy in the management of heart failure in patients who are not responding adequately to diuretics and digitalis. Lisinopril inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. The beneficial effects of lisinopril in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. Inhibition of ACE results in decreased plasma angiotensin II which leads to decreased vasopressor activity and to decreased aldosterone secretion. While the mechanism through which ZESTRIL lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, ZESTRIL is antihypertensive even in patients with low-renin hypertension.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0098 - $9.2170

Australia

$0.0625 - $0.2303
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( hydrochlorothiazide (esidrix), lisinopril (zestril) - other name: zestoretic )
6-acetamidocaproic acid | 6-acetamidohexanoic acid | 6-(acetylamino)hexanoic acid | acemin | acetaminocaproic acid | acexamic acid | anhydrous lisinopril | calcium acexamate | carace | cy168e | diroton | epsilon-acetamidocaproic acid | linopril | lisinopril | lisinopril anhydrous | lisinopril dihydrate | lisinopril hydrate | lisinoprilum | lisonopril | lisopress | mk-521 | [n2-[(s)-1-carboxy-3-phenylpropyl]-l-lysyl-l-proline | nanopril | prinivil | (s)-1-(n(2)-(1-carboxy-3-phenylpropyl)-l-lysyl)-l-proline | sodium acexamate | zestril | zinc acexamate

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