Title
Trial of Vitamin D3 Supplementation in Paediatric Asthma
Randomized, Double-blind, Placebo Controlled Trial of Vitamin D3 Supplementation on Clinical, and Subjective Symptoms of Paediatric Asthma
Phase
N/ALead Sponsor
University of DublinStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
AsthmaIntervention/Treatment
vitamin d3 ...Study Participants
53Epidemiological and observational studies have linked vitamin D deficiency with increased asthma/allergy incidence . Vitamin D insufficiency (<75nmol/L) has been associated with increased incidence of severe childhood asthma. Further, high 25(OH)D levels were associated with reduced risk of recent hospitalization, lower use of anti-asthmatic medication and lower airway hyper-responsiveness in childhood asthmatics. The association between vitamin D and allergy and asthma appears to be stronger in children than adults, with some even suggesting that childhood asthma may may be caused by VDD.
Asthmatic children will be recruited in winter. After baseline testing, children will be randomized to take 2,000iu vitamin D or placebo daily for 15 weeks. After the 15 weeks, testing will be repeated. Tests involve blood draws, questionnaires and breathing tests.
Soft gel capsules will be identical to the vitamin D intervention but contain no vitamin D.
Soft gel capsules will contain 2,000IU vitamin D.
2,000iu vitamin D3 per day for 15 weeks
An identical placebo capsule daily for 15 weeks.
Inclusion Criteria: Previous clinical diagnosis of asthma Ability to perform pulmonary function tests Established on anti-asthmatic pharmacotherapy with no expected change Exclusion Criteria: Use of medications that influence vitamin D metabolism or absorption Chronic, non-asthma medical issues e.g. endocrine, hepatic, renal, or bone-disease
