Title
Long-term Effects of Intensive Insulin Treatment in Type 1 Diabetes
Stockholm Diabetes Intervention Study
Phase
N/ALead Sponsor
Karolinska InstituteStudy Type
InterventionalStatus
Completed Results PostedIndication/Condition
Coronary Heart Disease Stroke Renal FailureIntervention/Treatment
insulin human ...Study Participants
102To investigate long-term effects on cardiovascular mortality/morbidity and renal failure in type 1 diabetes patients former randomized to intensive insulin treatment
The Stockholm Diabetes Intervention Study (SDIS) aimed to determine whether intensified insulin treatment were feasible and led to less serious diabetic complications. 102 patients with type 1 diabetes mellitus were randomized (October 1982 to March 1984) to intensified conventional treatment (ICT; n=48) or standard treatment (ST; n=54). The randomized SDIS study lasted for 7.5 years, whereas 96 patients were fully evaluated. Thereafter patients were assigned to their regular clinical visits.
In the present interventional study we wanted to study all-cause mortality and cardiovascular outcomes (i.e. myocardial infarction and stroke), and renal failure in the SDIS cohort until december 31 2011.
Mealtime insulin (Actrapid) Basal insulin (Monotard)
Insulin Mixtard
Intensive insulin treatment
Standard insulin treatment
Inclusion Criteria: Born 1930 or later Type 1 diabetes Nonproliferative retinopathy Normal serum creatinine Unsatisfactory blood glucose control Exclusion Criteria: Alcohol/drug abuse Proliferative retinopathy
| Event Type | Organ System | Event Term |
|---|
All cause mortality and composite mortality from myocardial infarction, stroke and renal failure
Morbidity of: coronary heart disease, stroke and renal failure
