Trial | NCT01924104  Report issue

Title

Effects of Aspirin and Low Molecular Weight Heparin in IVF Outcome.
Effects of Low Dose Aspirin and Low Molecular Weight Heparin Cotreatment, Alone and/or in Combination on Implantation and Clinical Pregnancy Rates in Repeated Implantation Failures in IVF Cycle.

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    400
The purpose of the study is to determine whether low-dose aspirin and low molecular weight heparin improve the implantation and pregnancy rates in patients with repeated implantation failures in IVF cycle.
The investigators hypothesize that cotreatment of low dose aspirin & low molecular weight heparin may improve implantation & clinical pregnancy rates.
Study Started
Aug 31
2013
Primary Completion
Aug 31
2014
Anticipated
Study Completion
Dec 31
2014
Anticipated
Last Update
Aug 16
2013
Estimate

Drug Low molecular weight heparin

2500 mIU/day, subcutaneously

  • Other names: LMWH

Drug Low dose aspirin

75 mg/day, orally

  • Other names: Ecoaspirin

Drug Heparin & aspirin

Aspirin (70 mg/day, orally) & heparin (40 mg/day, subcutaneously)

  • Other names: LMWH & Ecoaspirin

Other NaCl

Equivalent volume of NaCl 0.9%, subcutaneously

Low Molecular Weight Heparin Active Comparator

Low molecular weight heparin, 2500 milli-International unit/day, subcutaneously

Low dose aspirin Active Comparator

Low dose aspirin, 75mg/day, orally

Heparin & Aspirin Active Comparator

Heparin (40 mg/day, subcutaneously) and aspirin (70 mg/day, orally)

Sodium chloride (NaCl) Placebo Comparator

Equivalent volume of NaCl 0.9%, subcutaneously

Criteria 

Inclusion Criteria:

Aged between 19 to 35 years;
Basal follicle-stimulating hormone (FSH) levels of ≤8 IU/l
Body mass index (BMI) between 19 kg/m2 and 25 kg/m2
Presence of both ovaries; ≥2 previous IVF failures
Good quality embryos for transfer
Endometrial thickness between 10 mm and 14 mm

Exclusion Criteria:

Polycystic ovary syndrome
Endometriosis
No Results Posted