Active Ingredient History
Enoxaparin is a low molecular weight heparin used as anticoagulant medication to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) including during pregnancy and following certain types of surgery. Enoxaparin is a depolymerized derivative of Unfractionated heparin produced by controlled depolymerization using alkaline hydrolysis of the heparin benzylic ester. Like Unfractionated heparin, its major anticoagulant effect is mediated by interaction with antithrombin III, which in turn inactivates serine proteases like factors IIa (thrombin), IXa and Xa. Therefore, enoxaparin indirectly inhibits the conversion of prothrombin to thrombin and reduces the thrombin-mediated conversion of fibrinogen to fibrin, thus preventing clot formation. Among parenteral anticoagulants, enoxaparin stands out for certain major advantages: rapid onset of action, higher bioavailability, once- or twice-daily dosing that can be administered by patients at home without any need for monitoring, and no reported association with catheter thrombosis. Enoxaparin has been shown to be a safe and effective drug in a wide variety of thromboembolic conditions, and two decades of available data have undoubtedly inspired significant confidence. Although these properties make it a preferred option in a wide range of clinical disorders, lack of reliable antidote and accumulation in renal dysfunction are major concerns associated with its use, which are shared, apart from Unfractionated heparin, by most other available anticoagulants. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abdominal Neoplasms (Phase 3)
Abortion, Habitual (Phase 4)
Acute Coronary Syndrome (Phase 4)
Anesthesia (Phase 4)
Angina, Unstable (Phase 4)
Anticoagulants (Phase 4)
Antiphospholipid Syndrome (Phase 4)
Antithrombins (Phase 1/Phase 2)
Arrhythmias, Cardiac (Phase 3)
Arthroplasty, Replacement, Hip (Phase 3)
Arthroplasty, Replacement, Knee (Phase 3)
Atrial Fibrillation (Phase 4)
Bleeding Time (Phase 3)
Blood Coagulation (Phase 3)
Blood Loss, Surgical (Phase 4)
Blood Transfusion (Phase 4)
Brain Injuries (Phase 4)
Brain Injuries, Traumatic (Phase 4)
Carcinoma, Hepatocellular (Phase 3)
Carcinoma, Non-Small-Cell Lung (Phase 3)
Carcinoma, Small Cell (Phase 2)
Cardiovascular Diseases (Phase 2)
Carotid Artery Diseases (Phase 3)
Catheter-Related Infections (Phase 3)
Catheters (Phase 2)
Central Venous Catheters (Phase 2)
Cerebral Hemorrhage (Phase 4)
Cervix Uteri (Phase 3)
Cesarean Section (Phase 1)
Colorectal Neoplasms (Phase 3)
Contusions (Phase 4)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 4)
Coronavirus (Phase 2)
Coronavirus Infections (Phase 4)
COVID-19 (Phase 4)
Critical Illness (Phase 4)
Diabetes Mellitus, Type 1 (Phase 2)
Diabetic Angiopathies (Phase 2/Phase 3)
Diabetic Foot (Phase 3)
Drug Evaluation (Phase 3)
Drug Interactions (Phase 4)
Drugs, Investigational (Phase 3)
Embolic Stroke (Phase 2)
Embolism (Phase 3)
Embolism and Thrombosis (Phase 2)
Enoxaparin (Phase 4)
Esophageal Neoplasms (Phase 3)
Extracorporeal Membrane Oxygenation (Phase 3)
Factor X (Phase 4)
Femoral Neck Fractures (Phase 4)
Femur Head Necrosis (Phase 4)
Fertilization in Vitro (Phase 3)
Fetal Growth Retardation (Phase 3)
Fibrosis (Phase 4)
Gastrointestinal Neoplasms (Phase 4)
General Surgery (Phase 4)
Genital Neoplasms, Female (Phase 3)
Growth and Development (Phase 3)
Healthy Volunteers (Phase 2)
Heart Failure (Phase 4)
Heart Valve Diseases (Phase 4)
Hematoma (Phase 4)
Hemodialysis, Home (Phase 4)
Hemorrhage (Phase 4)
Hemorrhagic Stroke (Phase 3)
Heparin, Low-Molecular-Weight (Phase 3)
Hip Fractures (Phase 3)
Hip Injuries (Phase 3)
Hypertension (Phase 4)
Hypertension, Portal (Phase 4)
Infant, Premature, Diseases (Phase 3)
Infections (Phase 4)
Infertility (Phase 4)
Infertility, Female (Phase 4)
Inflammation (Phase 4)
Influenza A virus (Phase 3)
Influenza, Human (Phase 3)
Intestinal Neoplasms (Phase 4)
Ischemic Stroke (Phase 4)
Kidney Diseases (Phase 3)
Kidney Failure, Chronic (Phase 4)
Knee Injuries (Phase 3)
Laparoscopy (Phase 3)
Live Birth (Phase 3)
Liver Cirrhosis (Phase 4)
Liver Diseases (Phase 3)
Liver Neoplasms (Phase 4)
Liver Transplantation (Phase 3)
Lung Diseases (Phase 2)
Lung Neoplasms (Phase 1/Phase 2)
Lymphoma (Phase 1/Phase 2)
Mitral Valve (Phase 4)
Mouth Neoplasms (Phase 2/Phase 3)
Myocardial Ischemia (Phase 4)
Neoplasm Metastasis (Phase 4)
Neoplasms (Phase 4)
Nephrotic Syndrome (Phase 2/Phase 3)
Obesity (Phase 4)
Obesity, Morbid (Phase 1/Phase 2)
Osteoarthritis, Hip (Phase 4)
Osteoarthritis, Knee (Phase 4)
Osteosarcoma (Phase 4)
Ovarian Neoplasms (Phase 2)
Pancreatic Neoplasms (Phase 4)
Pediatrics (Phase 3)
Percutaneous Coronary Intervention (Phase 4)
Peripheral Arterial Disease (Phase 4)
Peritoneal Diseases (Phase 2)
Pharmacokinetics (Phase 4)
Placental Insufficiency (Phase 4)
Plastic Surgery Procedures (Phase 2)
Pneumonia (Phase 4)
Pneumonia, Bacterial (Phase 3)
Pneumonia, Viral (Phase 3)
Pre-Eclampsia (Phase 3)
Pregnancy (Phase 3)
Pregnancy Complications (Early Phase 1)
Pregnancy, High-Risk (Phase 4)
Pseudotumor Cerebri (Early Phase 1)
Pulmonary Embolism (Phase 4)
Purpura (Phase 1/Phase 2)
Radiation Oncology (Phase 2)
Renal Dialysis (Phase 4)
Renal Insufficiency (Phase 4)
Respiratory Insufficiency (Phase 3)
Retinal Diseases (Phase 3)
Rivaroxaban (Phase 3)
Sarcoma (Phase 4)
SARS-CoV-2 (Phase 4)
Sepsis (Phase 4)
Severe Acute Respiratory Syndrome (Phase 3)
Small Cell Lung Carcinoma (Phase 3)
Spinal Cord Injuries (Phase 2)
Splenectomy (Phase 4)
Staphylococcal Infections (Phase 2)
Stomach Neoplasms (Phase 3)
Stroke (Phase 4)
Thoracic Surgery (Phase 4)
Thrombocytopenia (Phase 4)
Thromboembolism (Phase 4)
Thrombophilia (Phase 3)
Thrombophlebitis (Phase 3)
Thrombosis (Phase 4)
Traumatology (Phase 4)
Upper Extremity Deep Vein Thrombosis (Phase 4)
Venous Cutdown (Phase 4)
Venous Thromboembolism (Phase 4)
Ventricular Dysfunction, Right (Phase 3)
Vertebral Artery Dissection (Phase 3)
Virus Diseases (Phase 2)
Vitreoretinopathy, Proliferative (Phase 3)
Vulvodynia (Phase 2)
Warfarin (Phase 4)
Wounds and Injuries (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
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