Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

• Patients must have signed a written informed consent form prior to any study specific procedures,

Women,
20 years or older,
Performance status < 2 (ECOG),
Histologically confirmed inflammatory breast cancer T4d any N,
hormonal Status known,
no metastases according to the last TNM classification,

adequate hematologic function :

absolute neutrophil count ≥ 1 500/mm3
Platelets ≥ 100 000/mm3
Hemoglobin ≥ 9 g/dL

adequate liver function :

ASAT and ALAT < à 3 ULN
Alkaline Phosphatase < 5 ULN
Total bilirubin < 1,5 ULN, o

adequate kidney function :

creatinine < 1,5 x normal or creatinine Clearance ≥ 50ml/min (according to the cockcroft and Gault formula)
Urine Dipstick for proteinuria < 2+ patients who have proteinuria ≥ 2 + on dipstick urinalysis at baseline should undergo a 24 hours urine collection and must demonstrate ≤ 1 g of protein in 24 hours,

adequate coagulation and cardiac function :

Prothrombin ratio ≥ 70 % and,
Prothrombin time ≤ 1,5 upper limit of normal (ULN) within 7 days prior to enrolment
Left Ventricular ejection fraction (LVEF) ≥ 55 %

Exclusion Criteria:

Patients of childbearing potential with a positive pregnancy test (serum or urine) prior to enrollment
Patients who are either not post-menopausal, or surgically sterile, not using "effective contraception" (the definition of "effective contraception" will be based on the judgment of the investigator)
Patients who are pregnant or breastfeeding
Patient considered socially or psychological unable to comply with the treatment and the required medial follow-up,
Concurrent participation in another clinical trial or treatment with any other anticancer agent during the protocol specified period
Patients unwilling or unable to sign and date an Ethics Committee (EC)/ Institutional Review Board (IRB)-approved patient informed consent form
Patients unwilling or unable to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures
Non inflammatory breast cancer with lymphatic skin permeation, Metastases,
Bilateral breast cancer
Distant metastases (stage IV)
History of another cancer other than adequately treated carcinoma in situ of the cervix uteri, basal or squamous cell skin cancer
Prior anti tumor therapy (surgery, radiotherapy, chemotherapy, hormonal treatment and targeted therapy) except treatments given for carcinoma in situ of the cervix uteri, basal or squamous cell skin cancer
History or evidence of inherited bleeding diathesis or coagulopathy,
History of thrombotic disorders within the last 6 months prior to enrollment (i.e. cerebrovascular accident, transient ischemic attacks, subarachnoid hemorrhage),
Uncontrolled hypertension (systolic > 150 mmHg and/or diastolic > 100 mmHg)with or without any anti-hypertensive medication ; patients with high initial blood pressure are eligible if entry criteria are met after initiation or adjustment of anti-hypertensive medication,
Any of the following within 6 months prior to enrollment:

myocardial infarction, severe/unstable angina, or coronary/peripheral artery bypass graft surgery, clinically symptomatic and uncontrolled cardiovascular disease, or clinically significant cardiac arrhythmias (grade 3-4)

Severe resting dyspnea due to complications or oxygen dependency,
Diabetic patient treated with oral anti-diabetics or insulin with an underlying cardiopathy at ultrasound,
Any other severe acute illness such as active uncontrolled infections that would preclude the safe administration of study therapy at the time of the enrolment
Other severe underlying medical conditions, which could impair the ability to participate in the study
Major surgery, significant traumatic injury within 28 days prior to study treatment start or anticipation of the need for major surgery during study treatment,
Minor surgery, including insertion of an indwelling catheter, within 24 hours prior to the first bevacizumab infusion,
Non-healing wound, active peptic ulcer or bone fracture,
History of abdominal fistula, diagnosed with a trachea-oesophageal fistula or any grade 4 non gastro-intestinal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months of enrolment,