Trial | NCT01759589  Report issue

Title

Three Anaesthesic Method in Electroconvulsive Theraphy
Sevoflurane Alone and Propofol With or Without Remifentanil in Electroconvulsive Therapy

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    39
To compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane in ECT.
The purpose of this study is to compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane) with respect to seizure duration, postictal suppression index, early and midictal amplitude, hemodynamic variables and recovery profiles in ECT.
Study Started
Jan 31
2011
Primary Completion
May 31
2011
Study Completion
Aug 31
2011
Last Update
Jan 03
2013
Estimate

Drug Propofol

1 mg/kg propofol IV (over 15 sec) during anesthesia induction

  • Other names: Intravenous anesthetic agent

Drug Remifentanil and propofol

1 µg/kg IV (over 60 sec)remifentanil and 0.5 mg/kg propofol IV (over 15 sec)during anesthesia induction

  • Other names: Opioid and intravenous anesthetic agent

Drug Sevoflurane

Sevoflurane was started at 6% for induction and continued at 1% until the electrical stimulus was delivered

  • Other names: Volatil anesthetic

propofol (Group P) Placebo Comparator

The patients in Group P received 1 mg/kg propofol IV (over 15 sec) during anesthesia induction

remifentanil and propofol (Group R) Active Comparator

Patients in Group R received remifentanil 1 µg/kg IV (over 60 sec) and 0.5 mg/kg propofol IV (over 15 sec)during anesthesia induction

sevoflurane (Group S) Active Comparator

In Group S, sevoflurane was started at 6% for induction and continued at 1% until the electrical stimulus was delivered, at which time it was stopped.

Criteria 

Inclusion Criteria:

Upremedicated ASA I-II (American Society of Anesthesiologists's physical status) patients,
Patients scheduled for six ECT sessions for a variety of psychiatric conditions (major depression, schizophrenia)

Exclusion Criteria:

Involuntary patient status
Patients with known or self-declared needle or mask phobia
Pregnancy
Asthma
Cerebrovascular disease,
History of myocardial infarction in the previous 6 months,
Atrial fibrillation or flutter,heart block,
A known or family history of reactions to the study drugs.
No Results Posted