Trial | NCT01370291  Report issue

Title

Repetitive Transcranial Magnetic Stimulation for First-episode Schizophrenia Patients
Repetitive Transcranial Magnetic Stimulation (rTMS) for First-episode Schizophrenia Patients:A Double-blinded , Randomized and Functional Magnetic Resonance Imaging (fMRI)Study

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    60
The aim of the study is to evaluate the effects of repetitive transcranial magnetic stimulation(rTMS)in the first-episode Schizophrenic patients: the clinical and MRI findings
Study Started
Jun 30
2011
Primary Completion
Dec 31
2012
Anticipated
Study Completion
Dec 31
2013
Anticipated
Last Update
Feb 15
2012
Estimate

Other active Risperidone and active rTMS

active Risperidone:------- active rTMS:auditory hallucinations:low-frequency(1Hz)applied over the left temporoparietal cortex(LTPC) negative symptoms:high-frequency（10Hz）applied over the left temporoparietal cortex(LTPC)

  • Other names: Risperidone:Xian-Janssen pharmaceutical ltd, rTMS:MagVenture

Other active rTMS and sham Risperidone

active Risperidone:------- ; active rTMS:auditory hallucinations:low-frequency(1Hz)applied over the left temporoparietal cortex(LTPC); negative symptoms:high-frequency（10Hz）applied over the left temporoparietal; cortex(LTPC)

  • Other names: Risperidone:Xian-Janssen pharmaceutical ltd, rTMS: MagVenture

Other sham rTMS and active Risperidone

active Risperidone:------- ; active rTMS:auditory hallucinations:low-frequency(1Hz)applied over the left temporoparietal cortex(LTPC); negative symptoms:high-frequency（10Hz）applied over the left temporoparietal; cortex(LTPC)

  • Other names: Risperidone:Xian-Janssen pharmaceutical ltd, rTMS: MagVenture

active Risperidone and active rTMS Active Comparator

active Risperidone and active rTMS for the first-episode schizophrenia patients

active rTMS and sham Risperidone Experimental

active rTMS and sham Risperidone for the first-episode schizophrenia

sham rTMS and active Risperidone Sham Comparator

sham rTMS and active Risperidone for the first-episode schizophrenia patients

Criteria 

Inclusion Criteria:

Age between 16-45 years
Diagnosis of schizophrenia according to DSM-IV criteria(by a board-certified psychiatrist)
PANSS>=60
First episode, and the patients haven't use any antipsychotic drugs

Exclusion Criteria:

Suicide risk
Diagnose of substance abuse/dependance
Severe uncontrolled organic disease that may interfere in the patient´s participation in the study

Contraindication to TMS:

Implanted pacemaker
Medication pump
Vagal stimulator
Deep brain stimulator
Metallic hardware in the head or scalp: shrapnel, surgical clips, or fragments from welding
Signs of increased intracranial pressure
Pregnancy or lactating; note that a negative pregnancy test will be required if the patient is a female in reproductive years
Estimated IQ less than 80
Have a sibling or parent with epilepsy
No Results Posted