Official Title
Vit D to Treat Asthma in Children: a Randomized, Double-blind, Placebo-controlled Trial
Phase
N/ALead Sponsor
United Arab Emirates UniversityStudy Type
InterventionalStatus
WithdrawnIndication/Condition
AsthmaIntervention/Treatment
Vitamin D3 (Cholecalciferol) ...Study Participants
0The purpose of this study is to determine whether vitamin D supplements can improve asthma control in children with moderate to severe asthma
The proposed interventional study will clarify the role of vitamin D in preventing asthma exacerbations and in achieving better chronic asthma control in children with moderate to severe asthma.
Vit D3 ( Cholecalciferol) 1200 IU oral daily for 6 months
Inclusion Criteria: Physician diagnosed asthmatics and they should fulfill at least two of the following three criteria: A minimum of three clinic visits for acute asthma within 1 year Two or more asthma-related hospital admissions within 1 year, or Steroid dependency, as defined by either 6 months of oral or 1 year of inhaled corticosteroid use Age: 6-14 years old. The age group of 6 to 14 years old was chosen for two reasons: Diagnostic accuracy of asthma is better in this age group as non-specific wheezers less than 6 years of age could be excluded. Child should be able to use a peak flow meter and perform spirometry tests. A positive specific IgE or a positive skin prick test for at least one airborne allergen. Exclusion Criteria: Children with mild intermittent and mild persistent asthma. Asthmatic children who are currently on immunotherapy or anti IgE. Asthmatic children with concomitant other medical problems. Children who are younger than 6 yrs or older than 14 yrs. Children with history of early life injury to airways like premature birth (< 36 weeks) or home use of oxygen. Children with vitamin D deficiency. Since these children may be randomized to the control group, they will be excluded for ethical reasons.
