Title
Effect of Vitamin D Supplementation on Muscle Mass and Function
Impact of Vitamin D Supplementation on Strength and Lean Mass Accumulation During an Exercise Intervention
Phase
Phase 4Lead Sponsor
Purdue UniversityStudy Type
InterventionalStatus
Completed Results PostedIndication/Condition
Obesity Insulin Resistance InflammationIntervention/Treatment
vitamin d3 ...Study Participants
34The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. The investigators hypothesis for these studies is that vitamin D supplementation enhances exercise-induced increases in strength and lean mass, potentially through enhancing insulin sensitivity and reducing inflammation.
The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. It was a double-blind, randomized, placebo-controlled, clinical trial with participants randomized into either a 4,000 IU/day vitamin D or placebo group and all participants completed 12 wks (3 d/wk) of exercise training.
4000 IU of vitamin D per day for 12 weeks.
Placebo (microcrystalline cellulose) ingestion each day for 12 weeks.
Participants in this arm consumed a 4000 IU vitamin D supplement daily for 12 weeks while participating in a resistance exercise training program.
Inclusion Criteria: Physical activity scores in the "low" to "very low" category Fitness estimations in the "below average" or lower categories body mass index scores >24.9 indicating overweight or obesity. Exclusion Criteria: Use of tanning booths or other artificial UV light exposure High baseline vitamin D and calcium intake Plans to visit sunny/warm destinations during the winter months/study period History or presence of metabolic disease, type 2 diabetes, eating disorders, gastrointestinal disorders, pregnancy or lactation Use of drugs to treat obesity (last 12 weeks) Use of over the counter anti-obesity agents (last 12 weeks) Recent initiation of an exercise program (last four weeks).
| Event Type | Organ System | Event Term |
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The primary endpoint is the change in lean mass (kilograms) after the three month resistance exercise intervention.
The primary endpoint is the change in the area under the glucose curve following an oral glucose tolerance test prior to and after the three month intervention.
The primary endpoint is the change in C reactive protein after the three month intervention
