Trial | NCT01069536  Report issue

Title

Efficacy and Akathisia Incidence of Slow Infusion Metoclopramide

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    140
Study Objective:

The purpose of this study is to compare the effects of metoclopramide administration in bolus versus slow infusion medications in ED patients complaining of nausea for the determination of the therapeutic effect and prevention of akathisia.

Methods:

This was a prospective, randomized, double-blind trial. The investigation was held between 01 March 2007 and 01 May 2008, in the Emergency Department of Pamukkale University Faculty of Medicine. The patients with moderate to severe nausea randomized and divided into two groups as for the previously planned administration type of drug. Ten mg metoclopramide was administered in one group with slow infusion (SIG) in 15 minutes, via 2 minutes bolus infusion (BIG) into the other group. Whole procedure was observed, akathisia and nausea scores and vital changes were recorded.
Study Started
Mar 31
2007
Primary Completion
Mar 31
2007
Study Completion
May 31
2008
Last Update
Feb 17
2010
Estimate

Drug metoclopramide 10 mg

2 minutes bolus infusion Active Comparator

15 minutes slow infusion Active Comparator

Criteria 

Inclusion Criteria:

Patients 18 through 65 years of age and 50-90 kg of weight who presented to the ED with primary or secondary complaints of moderate to severe nausea who not use of commonly accepted antiemetic within the previous 24 hours were eligible for this study.
Their peripheral oxygen saturation level was 90% or over while respirating room air and free of any respiratory problems.

Exclusion Criteria:

Patients with mild symptoms of nausea
Altered mental status
Abnormal vital signs
Any known allergy to the metoclopramide
Previously enrolled in the study
Known renal failure or insufficiency
GIS hemorrhage, ileus and/or perforation
Women who were pregnant and lactating
Those with a history of epilepsy
Admitted to the ED due to acute psychiatric symptoms
Restless legs syndrome
Parkinson
Organic brain disease
Phaeochromocytoma
Patient with alcohol
Anticholinergic, sedative, hypnotic, trankilizan, digoxin, cimetidine, tetracycline and levo-dopa use
Presence of severe agitation akathisia can not be evaluated and uncooperative individuals.
No Results Posted