Active Ingredient History
Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic. Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Metoclopramide also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramide's dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals. Metoclopramide is used for the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Gastroesophageal Reflux (approved 1980)
Gastroparesis (approved 1980)
Analgesics, Opioid (Phase 4)
Anemia, Refractory (Phase 3)
Anesthesia (Phase 4)
Anesthesia, Spinal (Phase 4)
Angina, Unstable (Phase 4)
Autonomic Nervous System Diseases (Phase 3)
Bariatric Surgery (Phase 3)
Breast Feeding (Phase 3)
Cesarean Section (Phase 4)
Colonic Neoplasms (Phase 3)
Critical Illness (Phase 4)
Dexamethasone (Phase 4)
Diabetes Mellitus (Phase 3)
Dopamine beta-Hydroxylase (Phase 3)
Drug Delivery Systems (Phase 3)
Dyspepsia (Phase 3)
Endoscopy (Phase 4)
Enteral Nutrition (Phase 2)
Esophageal Neoplasms (Phase 4)
Gastric Emptying (Phase 4)
Gastroenteritis (Phase 4)
Gastroesophageal Reflux (Phase 4)
Gastrointestinal Hemorrhage (Phase 3)
Gastroparesis (Phase 2)
Gastroschisis (Phase 3)
General Surgery (Phase 3)
Headache (Phase 4)
Hemorrhage (Phase 4)
Hiccup (Phase 4)
HIV Infections (Phase 3)
Hyperemesis Gravidarum (Phase 3)
Hypoglycemia (Phase 2)
Hypotension, Orthostatic (Phase 3)
Infant, Newborn, Diseases (Phase 2)
Infant, Premature (Phase 4)
Intestinal Diseases (Phase 3)
Intestinal Neoplasms (Phase 4)
Labor, Induced (Phase 1)
Labor, Obstetric (Phase 4)
Laparoscopy (Phase 4)
Leukemia, Myeloid, Acute (Phase 3)
Macular Degeneration (Phase 1)
Metabolism (Phase 1)
Metoclopramide (Phase 4)
Migraine Disorders (Phase 4)
Migraine with Aura (Phase 4)
Migraine without Aura (Phase 4)
Myelodysplastic Syndromes (Phase 2)
Myocardial Infarction (Phase 4)
Nausea (Phase 4)
Neoplasm Metastasis (Phase 2)
Neoplasms (Phase 4)
Orthostatic Intolerance (Phase 3)
Pain, Postoperative (Phase 4)
Pancreatic Neoplasms (Phase 1/Phase 2)
Personal Satisfaction (Phase 4)
Pharmacokinetics (Phase 4)
Pneumonia, Aspiration (Phase 4)
Postoperative Complications (Phase 4)
Postoperative Nausea and Vomiting (Phase 4)
Post-Traumatic Headache (Phase 4)
Pregnancy (Phase 4)
Pregnancy Complications (Phase 2)
Prostatic Neoplasms (Phase 4)
Psychomotor Agitation (Phase 4)
Radiation Exposure (Phase 2)
Randomized Controlled Trial (Phase 4)
Respiratory Aspiration (Phase 4)
Saliva (Phase 3)
Sepsis (Phase 3)
Signs and Symptoms (Phase 4)
ST Elevation Myocardial Infarction (Phase 4)
Stomach Diseases (Early Phase 1)
Stroke (Phase 4)
Ventilators, Mechanical (Phase 4)
Vertigo (Phase 4)
Vomiting (Phase 4)
Wounds and Injuries (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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