Active Ingredient History

NOW
  • Now
Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic. Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Metoclopramide also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramide's dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals. Metoclopramide is used for the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.   NCATS

More Chemistry

Drug Pricing (per unit)

United States

$0.0400 - $3.8000

Australia

$0.0453 - $0.4427
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

2-methoxy-4-amino-5-chloro-n,n-(dimethylaminoethyl)benzamide | 2-methoxy-5-chloroprocainamide | 4-amino-5-chloro-2-methoxy-n-(β-diethylaminoethyl)benzamide | 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamide | ahr-3070-c | clopra | clopra-yellow | gastrese l.a. | gastrobid continus | gastroflux | gastromax | maxolon | maxolon sr | metaclopramide | metclopramide | methochlopramide | metochlopramide | metoclomex | metoclopramida | metoclopramide | metoclopramide hcl | metoclopramide hydrochloride | metoclopramide hydrochloride hydrate | metoclopramide intensol | metoclopramide monohydrochloride | metoclopramidum | metox | metozolv odt | metramid | mygdalon | parmid | primperan | reglan | reglan odt

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue