Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

Age > 65 year old and not a candidate for stem cell transplant, or younger who refuses or is not eligible for high-dose therapy
Symptomatic multiple myeloma or asymptomatic multiple myeloma with related organ or tissue damage
Presence of measurable disease
Karnofsky performance status (PS) > 60%
Able to read and complete the HRQOL instruments
Agrees to use an acceptable barrier method for contraception for the duration of the study
Pretreatment clinical laboratory values within 14 days of randomization:

platelet count ≥ 100x109/L

hemoglobin ≥ 8 g/dL
absolute neutrophil count (ANC) ≥ 1.0x109/L
AST ≤ 2.5 times the upper limit of normal
ALT ≤ 2.5 times the upper limit of normal
total bilirubin ≤ 1.5 times the upper limit of normal
serum creatinine ≤ 2.5mg/dL
corrected serum calcium <14 mg/dL (<3.5 mmol/L)
Subjects (or their legally acceptable representatives) must have signed an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study.
Women of child-bearing potential must agree to use 2 methods of contraception: 1 effective (for example hormonal or tubal ligation) and 1 barrier (for example latex condom, diaphragm) for at least 4 weeks before starting the therapy, during the Treatment Period, and for 4 weeks after the last dose;
Males must agree to use barrier contraception (latex condoms) when engaging in reproductive activity during the Treatment Period and for 4 weeks after the last dose.

Exclusion Criteria:

Diagnosis of smoldering multiple myeloma or MGUS.
Diagnosis of Waldenstrom's disease
Prior or current systemic therapy for multiple myeloma including steroids (with exception of emergency use of a short course [maximum 4 days] of steroids before randomization or prior or current use of biphosphonates)
Radiation therapy within 30 days before randomization
Plasmapheresis within 30 days before randomization
Major surgery within 30 days before randomization (Kyphoplasty is not considered major surgery)
History of allergic reaction attributable to compounds containing boron or mannitol, or to Thalidomide
Peripheral neuropathy Grade 2 or higher, as defined by National Cancer Institute Common Toxicity Criteria (NCI CTC) 3.0
Uncontrolled or severe cardiovascular disease including myocardial infarction within 6 months of enrollment, New York Heart Association (NYHA) Class III or IV heart failure, uncontrolled angina, clinically significant pericardial disease, or cardiac amyloidosis
Other malignancy within the past 5 years. Exceptions: basal cell or non metastatic squamous cell carcinoma of the skin, cervical carcinoma in situ or FIGO Stage 1 carcinoma of the cervix
Concurrent medical condition or disease (e.g., active systemic infection, uncontrolled diabetes, pulmonary disease) that is likely to interfere with study procedures or results, or that in the opinion of the investigator would constitute a hazard for participating in this study
Use of any investigational drugs within 30 days before randomization.
Pregnant or lactating women. A serum β-hCG pregnancy test must be performed at the Screening visit, for female patients of child-bearing potential. If the test is positive, the patient must be excluded from the study. Confirmation that the patient is not pregnant must be established by a negative serum or urinary pregnancy test with the result obtained 1 day prior to the Baseline visit (or the day of the visit if results are available before drug delivery).