Trial | NCT01032031  Report issue

Title

The Effect of Green Tea and Vitamin C on Skin Health
The Effect of Dietary Bioactive Compounds on Skin Health in Humans in Vivo

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    vitamin c tea ...

  • Study Participants

    95
There is little information on the effect of oral bioactive compounds on human skin clinically despite evidence of a beneficial effect from laboratory studies. The aim of this study is to examine the effect of oral bioactive compounds (green tea and vitamin C) on the health of human skin by measuring markers of skin health directly and skin nutrient uptake.
There is little information on the effect of oral catechin, a nutritionally relevant bioactive compound, on skin health in humans in vivo despite considerable evidence for protective effects in experimental studies. Vitamin C is essential for skin health and stabilises catechins in the gut lumen. Ultraviolet radiation (UVR) in sunlight is a key environmental stressor impacting on skin health. Effects include acute inflammation and longer term photodamage.

OBJECTIVE: To examine the protective effect of catechin and vitamin C on UVR-induced inflammation.

STUDY DESIGN

(1) A double-blind randomised controlled nutritional study in 50 healthy volunteers. Volunteers will receive 3 months dietary supplement with high dose bioactive (n=25),or placebo (n=25).

The aim is to quantify the influence of catechin/vitamin C on:

UVR-induced inflammation
Leukocyte infiltration
Inflammatory mediators
Markers of photoageing
DNA damage
Bioavailability will also be assessed

(2) Bioavailability of catechin and vitamin C in skin and blood. Volunteers will receive active dietary supplement. Blood and urine samples will be taken over a period of 6 hours to determine blood bioavailability. Skin biopsies will also be taken to assess skin bioavailability. Volunteers will then receive 3 months of active dietary supplement followed by repeated sampling.
Study Started
Mar 31
2009
Primary Completion
Aug 31
2012
Study Completion
Aug 31
2012
Last Update
Mar 08
2016
Estimate

Dietary Supplement Green tea + vitamin C high dose

One green tea capsule (1250mg catechin) and one vitamin C tablet (100mg) daily for 3 months

Dietary Supplement Placebo capsule

One capsule daily for 3 months

Green tea + vit C high dose Active Comparator

Placebo Placebo Comparator

Criteria 

Inclusion Criteria:

Healthy adults
Sun-reactive skin type I / II

Exclusion Criteria:

History of skin cancer
History of a photosensitivity disorder
History of a generalised skin disorder
Sunbathing (including sunbeds) in the past 3 months
Pregnancy
Taking photoactive medicine
Drink tea > 2 cups/day
Taking nutritional supplements
No Results Posted