Trial | NCT01008488  Report issue

Title

Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis
Is Antibiotic Therapy Mandatory for Treatment of Uncomplicated Acute Colonic Diverticulitis: a Randomized Clinical Trial

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    cefazolin ...

  • Study Participants

    600
The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis.

The hypothesis is that Patients with acute uncomplicated colonic diverticulitis will recover the condition without antibiotic therapy and the lack of antibiotic therapy will not lead to complications.

The patients will be randomized to conservative treatment with and without antibiotic therapy.
Study Started
Nov 30
2002
Primary Completion
May 31
2010
Study Completion
Dec 31
2010
Last Update
Dec 23
2011
Estimate

Drug Antibiotic

Antibiotic according to local treatment routine against bowel pathogenesis

Antibiotic Active Comparator

No antibiotic No Intervention

Criteria 

Inclusion Criteria:

adults with CT sign of acute colonic uncomplicated diverticulitis
elevated CRP and LPK
Temp.38c or more

Exclusion Criteria:

patients with peritonitis, sepsis or CT- sign of complicated diverticulitis with abscesses or free abdominal air
pregnancy
immunological incompetence and immunosuppressive therapy
No Results Posted