Active Ingredient History
Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cefazolin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. Cefazolin is used to treat bacterial infections of the skin, moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. This drug also can be used for perioperative prophylaxis. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Respiratory Tract Infections (approved 1973)
Urinary Tract Infections (approved 1973)
Abscess (Phase 4)
Analgesics, Opioid (Phase 4)
Anesthesia (Phase 4)
Anti-Bacterial Agents (Phase 4)
Antibiotic Prophylaxis (Phase 4)
Aortic Valve Disease (Phase 4)
Arrhythmias, Cardiac (Phase 4)
Arthritis, Infectious (Phase 4)
Arthropathy, Neurogenic (Phase 4)
Azithromycin (Phase 4)
Bacteremia (Phase 3)
Bacterial Infections (Phase 4)
Bariatric Surgery (Phase 4)
Bone Diseases (Phase 4)
Bone Diseases, Infectious (Phase 4)
Bone Neoplasms (Phase 3)
Breast Diseases (Phase 4)
Burns (Phase 4)
Carcinoma, Hepatocellular (Phase 4)
Carpal Tunnel Syndrome (Phase 4)
Catheter-Related Infections (Phase 3)
Cefazolin (Phase 4)
Cellulitis (Phase 3)
Central Nervous System Infections (Phase 4)
Cesarean Section (Phase 4)
Community-Acquired Infections (Phase 3)
Craniotomy (Phase 1/Phase 2)
Critical Illness (Phase 2)
Cross Infection (Phase 2)
Cystitis (Phase 4)
Diabetes Mellitus (Phase 4)
Empyema (Phase 4)
Endometritis (Phase 4)
Endophthalmitis (Phase 4)
Fever (Phase 2)
Fractures, Bone (Phase 4)
Fractures, Open (Phase 4)
Gastrointestinal Microbiome (Early Phase 1)
General Surgery (Phase 4)
Gram-Positive Bacterial Infections (Phase 3)
Hamartoma (Phase 4)
Hand Injuries (Phase 4)
Healthy Volunteers (Phase 1)
Heart Defects, Congenital (Phase 4)
Hemopneumothorax (Phase 2/Phase 3)
Hernia, Inguinal (Phase 4)
Implant Capsular Contracture (Phase 3)
Infant, Premature (Phase 3)
Infant, Premature, Diseases (Phase 1)
Infections (Phase 4)
Keratitis (Phase 3)
Knee Injuries (Phase 4)
Labor, Obstetric (Early Phase 1)
Lacerations (Phase 4)
Laryngeal Neoplasms (Phase 3)
Mammaplasty (Phase 1)
Melanoma (Phase 1)
Multiple Myeloma (Phase 1)
Neoplasms (Phase 3)
Obesity (Phase 4)
Obesity, Morbid (Phase 4)
Obstetric Labor Complications (Phase 4)
Obstetric Labor, Premature (Phase 4)
Obstetrics (Phase 4)
Osteoarthritis (Phase 4)
Osteoarthritis, Hip (Phase 4)
Osteomyelitis (Phase 4)
Peritoneal Dialysis (Phase 4)
Pharmacokinetics (Phase 1)
Physiological Effects of Drugs (Phase 4)
Pleural Effusion (Phase 4)
Pleurisy (Phase 4)
Pneumonia (Phase 2)
Pneumonia, Pneumococcal (Phase 3)
Pneumothorax (Phase 2/Phase 3)
Postoperative Complications (Phase 4)
Postpartum Hemorrhage (Phase 4)
Postpartum Period (Phase 4)
Pregnancy (Phase 4)
Pregnancy Complications (Phase 4)
Premature Birth (Phase 4)
Prostatic Neoplasms (Phase 3)
Prostheses and Implants (Phase 3)
Prosthesis-Related Infections (Phase 2)
Psychological Distress (Phase 2/Phase 3)
Pyelonephritis (Phase 4)
Renal Replacement Therapy (Phase 1)
Sepsis (Phase 3)
Shock, Septic (Phase 2)
Skin Diseases, Bacterial (Phase 3)
Skin Diseases, Infectious (Phase 3)
Staphylococcal Infections (Phase 4)
Surgical Wound Infection (Phase 4)
Systemic Inflammatory Response Syndrome (Phase 2)
Tendon Injuries (Phase 4)
Uterine Cervical Incompetence (Phase 4)
Venous Thromboembolism (Phase 2/Phase 3)
Vitreoretinal Surgery (Phase 4)
Vulvar Neoplasms (Phase 2)
Wound Infection (Phase 4)
Trial | Phase | Start Date | Organizations | Indications |
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