Trial | NCT00941837  Report issue

Title

Effect of Dietary Fat Type in Combination With High Protein on Plasma Homocysteine Levels
Effect of Dietary Fat Type in Combination With High Protein on Plasma Homocysteine Levels and Selected Markers of Cardiovascular Heart Disease Risk in Human Volunteers

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    45
In this study, the investigators address the research question of whether palm olein will have a positive influence on plasma total homocysteine levels in human volunteers provided with high-protein diets formulated from common Malaysian foods.

Hypothesis: There is a significant difference on the effects of the three experimental oils (palm olein, olive and coconut oil) on plasma tHy levels and the other markers of coronary heart disease (CHD) risk measured.
The experimental are comprise of 30% kcal fat, 20% kcal protein and 50% kcal carbohydrate. Each of the test fat [palm olein (POo), virgin olive oil (OO) and coconut oil (CO)] contributes to two-thirds of total dietary fat will be compared.

Three meals a day providing 2000 kcal, including breakfast, lunch and dinner will be provided for the 5-weeks period of each fat rotation.

45 volunteers are fed with normal cooking oil for 3 weeks for standardisation purpose. They were then stratified into 3 groups according to gender, homocysteine and cholesterol level. The volunteers will be randomized, blinded and will undergo a 3 arms crossover intervention. Each intervention will take 5 wk with 2 wk wash out in between.

Baseline blood samples will be taken while other blood samples will be collected at week-4 and -5 of the study.
Study Started
Feb 28
2009
Primary Completion
Jul 31
2009
Study Completion
Oct 31
2010
Last Update
Jun 08
2011
Estimate

Dietary Supplement Olive Oil, Palm Olein Oil, Coconut Oil

Effect of dietary fat type in combination with high protein on plasma homocysteine levels; 5 wk each with 2 wk wash out in between

Olive Oil Experimental

Coconut oil Experimental

Palm Olein Experimental

Criteria 

Inclusion Criteria:

Apparently healthy adult males and females aged 20-60 years, with BMI 23.0 -29.9 kg/m2, and free from any disease (will be decided through history taking, physical examination and biochemical tests).
Not on any medication or treatment associated with reduction of CHD.
Non-smokers and non heavy drinker or having smoking or alcoholic history.
Not pregnant or lactating.
Willing to adhere to the Dietary Guidelines to the study.

Exclusion Criteria:

Obese [Body Mass Index (BMI) ≥ 30] or grossly underweight (BMI < 18).
Suffering from chronic diseases such as diabetes mellitus, CHD, cancer or any liver/renal disease.
People with blood clotting problem.
Hypertensive persons (systolic pressure > 140 mmHg, diastolic pressure > 90 mmHg)
No Results Posted