Trial | NCT00869427  Report issue

Official Title

Vitamin C for Prevention of Urinary Tract Infections in the Spinal Cord Injured

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Terminated

  • Intervention/Treatment

    vitamin c ...

  • Study Participants

    40
After spinal cord injury, patients have frequent urinary tract infections (UVI). Vitamin C is usually prescribed to prevent such infection, but the efficacy of the treatment is poorly documented. In the study, patients will be randomised either to receive vitamin C daily, or not, for one year, and clinical episodes of UVI will be registered. The null hypothesis is that vitamin C will not reduce the number of UVI episodes by 30%.
The study is an investigator-blind randomised parallel study on the efficacy of vitamin C to prevent urinary tract infections in stable, ambulatory spinal cord-injured patients. To be included, patients should have had at least 3 previous UVI episodes over the last two years. 40 patients are included. Patients are randomised to receive either 1 g vitamin C b.i.d. over 1 year, or no vitamin C. The main outcome is the number of clinical UVIs that have been treated with antibiotics.
Study Started
Mar 31
2009
Primary Completion
Jun 30
2011
Anticipated
Study Completion
Jun 30
2011
Anticipated
Last Update
Jul 05
2010
Estimate

Drug vitamin C

vitamin C 1g bid for 1 year

1 vitamin C Active Comparator

Vitamin C 1g bid

2 No Intervention

Usual Care

Criteria 

Inclusion Criteria:

spinal cord injury
3 or more episodes of UVI over previous 2 years

Exclusion Criteria:

pregnancy
age <18
continuous use of antibiotics, hippuric acid or crane berry juice
No Results Posted