Trial | NCT00857519  Report issue

Title

A Study of the Effectiveness of a Local Injection of Chemotherapy for Retinoblastoma
Intra-arterial (Ophthalmic Artery) Chemotherapy for Retinoblastoma

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    10
Over the past 15 years, intravenous chemotherapy has become the most popular conservative (eye-saving) method for retinoblastoma treatment because it is often effective and usually safe. In recent years, there has been much interest in providing highly focused (focal) chemotherapy to a diseased organ including the liver, brain, and eye. With focused chemotherapy, the chemotherapy drugs are injected directly into the ophthalmic artery (the artery that supplies blood to the eye). A benefit of focal chemotherapy delivery is that it decreases the chance of toxicity to other organs such as bone marrow suppression (causing low blood counts) and the development of other cancers in the future.
The management of retinoblastoma includes systemic chemotherapy (carboplatin, etoposide, and vincristine), thermotherapy, cryotherapy (freezing treatment), laser photocoagulation, plaque radiotherapy, external beam radiotherapy, and enucleation. The treatment is tailored to each individual case. Over the past 15 years, intravenous chemotherapy has risen as the most popular conservative (eye-saving) method for retinoblastoma management because it is effective and safe. In recent years, there has been keen interest in providing chemotherapy more focally to a diseased organ including the liver, brain, and eye. The benefit of focal chemotherapy delivery is to avoid toxicity to other organs and this toxicity includes the risk of future cancers.
Study Started
Jan 31
2009
Primary Completion
Mar 31
2014
Study Completion
Apr 30
2014
Last Update
Dec 12
2016
Estimate

Drug Melphalan, Carboplatin

Intra-arterial chemotherapy.

  • Other names: ALKERAN,PARAPLATIN

Chemotherapy Experimental

Chemotherapy using Melphalan, Carboplatin.

Criteria 

Inclusion Criteria:

Advanced retinoblastoma in one or both eyes
Recurrent retinoblastoma after failure of previous treatment
No age limit (usually kids presenting with retinoblastoma present in the 1st two decades of life)
Judged by principal investigator to be medically and physically able to undergo the procedure

Exclusion Criteria:

Recurrent retinoblastoma which is treatable with other conservative measures
Invasive retinoblastoma (retinoblastoma that has grown locally outside of the eye, for example, into the bone around the eye)
No Results Posted