Trial | NCT00828399  Report issue

Title

Prevention of Acute Radiation Enteritis With Glutamine
Efficacy of Glutamine in the Prevention of Acute Radiation Enteritis Among Patients Treated With Radiation of Abdomen and Pelvis.

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Indication/Condition

    Acute Radiation Enteritis

  • Intervention/Treatment

    Glutamine ...

  • Study Participants

    70
Ionizing radiation has cytotoxic effects, and is commonly used as treatment for neoplasm. A common adverse effect of radiation is acute diarrhoea. Glutamine is an aminoacid with antioxidant effects that can protect tissues of damage dued to radiation. The investigators designed a randomized, double-blind trial phase III to study if glutamine prevents acute radiation enteritis.
Study Started
Jan 31
2009
Primary Completion
May 31
2011
Study Completion
May 31
2011
Last Update
May 25
2011
Estimate

Dietary Supplement Glutamine

Oral glutamine 30g/day

Dietary Supplement Whole protein

Oral whole protein 30 g/day

Glutamine Experimental

Whole protein Placebo Comparator

Criteria 

Inclusion Criteria:

Age > 18 yr
Gynaecological,prostatic, rectal or other abdominal cancer
Radiotherapy with/without chemotherapy

Exclusion Criteria:

life expectancy < 1 yr
Age < 18 yr
gut diseases: inflammatory bowel disease,sprue, irritable bowel disease...
moderate to severe chronic renal failure
hepatic cirrhosis
No Results Posted