Title
Fermented Milk Drink on Human Intestinal Microflora
Effects of a Fermented Milk Drink Containing Lactobacillus Casei Strain Shirota on the Human Intestinal Microflora
Phase
Phase 2Lead Sponsor
Cheng Hsin Rehabilitation Medical CenterStudy Type
InterventionalStatus
Completed Results PostedIndication/Condition
Signs and Symptoms, DigestiveIntervention/Treatment
autologous microbiome lactobacillus casei ...Study Participants
24Fermented milk is a popular drink. Recent studies revealed that some fermented milk containing some strains of lactic acid bacteria have health-promoting effects through improvement of the intestinal microflora and modulation of the immune system. Lactobacillus casei strain Shirota (LcS) is a probiotic bacterium used in the production of fermented milk products and lactic acid bacteria preparations. LcS has been shown to modify allergen-induced immune responses in allergic rhinitis, altering fermentation patterns in the small bowel, prevention of recurrent urinary tract infections in women. Yakult®300 is a fermented milk containing at least 3x10^10 live LcS cells per 100 ml bottle. This study aimed to evaluate the effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human intestinal microflora.
Yakult®300 was given 100 ml once per day for four weeks. Fermented or unfermented milk per 100 ml bottle per day for four week.
Lactobacillus casei strain Shirota
Fermented milk with Lactobacillus casei strain Shirota 100ml per day
Unfermented milk without Lactobacillus casei strain Shirota 100ml per day
Inclusion Criteria: Healthy adult volunteers and willing to give voluntary written informed consent Exclusion Criteria: Major systemic disease Pregnancy, parturient and feeding woman, or expect to be pregnant Abnormal liver function Abnormal renal function Abnormal gastrointestinal function Take medication for gastrointestinal function Stroke, myocardial infarction, Poor compliance for study protocol
| Event Type | Organ System | Event Term |
|---|
Fecal specimens were obtained from all 24 healthy volunteers at week 0, 1, 2, 3, 4, 5, 6. Bifidobacterium was cultured. Bacterial colonies were counted.
Fecal specimens were obtained from all 24 healthy volunteers at week 0, 1, 2, 3, 4, 5, 6. Clostridium perfringens was cultured.Bacterial colonies were counted.
Fecal specimens were obtained from all 24 healthy volunteers at week 0, 1, 2, 3, 4, 5, 6. Bacterial colonies were cultured and counted.
Outcome Measure Data Not Reported
