Trial | NCT00636584  Report issue

Title

Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function
Does Sodium Nitroprusside Infusion Affect Thyroidal Function in Patients Undergoing Coronary Artery Bypass Grafting, a Prospective Randomized Clinical Trial.

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Unknown status

  • Intervention/Treatment

    nitroprusside ...

  • Study Participants

    106
Whether use of SNP during cardiac surgery has any effect on thyroid function has not yet been investigated in humans. The aim of this study was to investigate the effects of SNP administration during the rewarming period of cardiac operations on circulating levels of thyroid hormones.
Study Started
Feb 29
2008
Primary Completion
Feb 29
2008
Study Completion
Mar 31
2008
Anticipated
Last Update
Mar 14
2008
Estimate

Drug sodium nitroprusside

sodium nitroprusside infusion at 1 microgram/kg/min dose during rewarming period of cardiac operations

  • Other names: nipruss

Drug placebo

placebo

1 Experimental

arm1: sodium nitroprusside group

2 Placebo Comparator

arm2: control group,saline infused instead of sodium nitroprusside

Criteria 

Inclusion Criteria:

Patients without history of:

thyroidal disease
hypertension
pulmonary disease
peripheral vascular disease
stroke
recent myocardial infarction within the week prior to operation
unstable angina pectoris
liver or kidney dysfunction
morbid obesity
cachexia
sulfonylurea intake

Exclusion Criteria:

Patients who needed positive inotropic pharmacologic support during or after the operation
Patients who developed atrial fibrillation in the post operative period requiring amiodarone therapy

In addition, patients receiving any medication known to interfere with any step of thyroid hormone metabolism such as

amiodarone
propranolol
furosemide
non-steroidal anti-inflammatory agents
steroids
estrogens
antacids
diphenylhydantoin
spironolactone
No Results Posted