Trial | NCT00634491  Report issue

Title

Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy
Effect of Acetazolamide in Prevention of Contrast Nephropathy

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    240
The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy
Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.
Study Started
Sep 30
2007
Primary Completion
Feb 29
2008
Study Completion
Feb 29
2008
Last Update
Mar 13
2008
Estimate

Drug sodium bicarbonate

150 meq/l Sodium bicarbonate 3cc/kg/hr before and 1cc/kg/hr after angiography

  • Other names: no other name

Drug Acetazolamide

Acetazolamide 250 mg+ 1 cc/kg/hr normal salin before and after angiography

  • Other names: Diamox

Drug normal salin

1 cc/kg/hr 6 hour before and after angiography

  • Other names: no other name

1 Active Comparator

150 meq/l NaHco3 3cc/kg/hr one Hour before and 1cc/kg/hr 6 hour after angiography

2 Active Comparator

Acetazolamide 250 mg + 1cc/kg/hr normal salin 6 hour before and after angiography

3 Active Comparator

normal salin 1cc/kg/hr before and after angiography

Criteria 

Inclusion Criteria:

patient that underwent coronary angiography

Exclusion Criteria:

serum Cr. more than 3 mg/dl
electrolyte and acid-base imbalance
pulmonary edema
allergy to Acetazolamide
No Results Posted