Active Ingredient History
Acetazolamide, usually sold under the trade name Diamox in some countries. DIAMOX is used for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. DIAMOX is also indicated for the prevention or amelioration of symptoms associated with acute mountain sickness despite gradual ascent. DIAMOX is an enzyme inhibitor that acts specifically on carbonic anhydrase, the enzyme that catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In the eye, this inhibitory action of acetazolamide decreases the secretion of aqueous humor and results in a drop in intraocular pressure, a reaction considered desirable in cases of glaucoma and even in certain non-glaucomatous conditions. Evidence seems to indicate that DIAMOX has utility as an adjuvant in treatment of certain dysfunctions of the central nervous system (e.g., epilepsy). The diuretic effect of DIAMOX is due to its action in the kidney on the reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. The result is renal loss of HCO3 ion, which carries out sodium, water, and potassium. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Glaucoma, Open-Angle (approved 1953)
Abdominoplasty (Phase 4)
Aging (Early Phase 1)
Alkalosis (Phase 4)
Allergy and Immunology (Phase 1)
Analgesics, Opioid (Phase 2)
Andersen Syndrome (Phase 1)
Aneurysm (Phase 4)
Blood Coagulation (Phase 2)
Blood Pressure (Phase 2)
Carcinoma, Hepatocellular (Phase 3)
Cerebrospinal Fluid Leak (Phase 2)
Chronic Pain (Phase 2)
Cocaine-Related Disorders (Phase 1)
Cognition Disorders (Phase 3)
Compliance (Phase 2)
Congenital Disorders of Glycosylation (Phase 2/Phase 3)
Coronary Vasospasm (Phase 2)
Diabetes Mellitus, Type 1 (Phase 1/Phase 2)
Diabetic Retinopathy (Phase 2)
Edema (Phase 4)
Fibrinolysis (Phase 3)
Geriatrics (Phase 4)
Glaucoma ()
Glioma (Phase 1)
Healthy Volunteers (Phase 1)
Heart Diseases (Phase 3)
Heart Failure (Phase 4)
Helicobacter pylori (Phase 2)
Hemodilution (Phase 3)
Hydrocephalus, Normal Pressure (Phase 2)
Hyperalgesia (Phase 4)
Hypertension (Phase 2)
Hypertension, Pulmonary (Phase 4)
Hypotension, Orthostatic (Phase 1)
Hypoxia (Phase 4)
Kidney Diseases (Phase 2)
Landau-Kleffner Syndrome (Phase 2/Phase 3)
Lipoma (Phase 2)
Macular Degeneration (Phase 2)
Macular Edema (Phase 2)
Melanoma (Phase 1)
Men (Phase 1)
Metabolic Diseases (Phase 3)
Motor Activity (Phase 3)
Multiple Sclerosis (Phase 1/Phase 2)
Neoplasms (Phase 2)
Nephrotic Syndrome (Phase 4)
Neural Tube Defects (Phase 2)
Neurocysticercosis (Phase 2/Phase 3)
Obesity (Early Phase 1)
Obesity Hypoventilation Syndrome (Phase 3)
Opioid-Related Disorders (Phase 4)
Orthostatic Intolerance (Phase 1/Phase 2)
Pharmacokinetics (Phase 1)
Pharmacology (Phase 4)
Polycythemia (Phase 4)
Prostatic Neoplasms (Phase 1)
Pseudotumor Cerebri (Phase 3)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Pure Autonomic Failure (Phase 1)
Respiratory Insufficiency (Phase 4)
Retinal Artery Occlusion (Phase 3)
Retinoschisis (Phase 2)
Schizophrenia (Phase 1/Phase 2)
Sleep Apnea, Central (Phase 4)
Sleep Apnea, Obstructive (Phase 4)
Sleep Apnea Syndromes (Phase 4)
Sleep Disorders, Intrinsic (Phase 2)
Small Cell Lung Carcinoma (Phase 1)
Spina Bifida Occulta (Phase 2)
Status Epilepticus (Phase 2/Phase 3)
Stroke (Phase 3)
Subarachnoid Hemorrhage (Phase 4)
Tachycardia (Phase 1/Phase 2)
Umbilical Cord (Phase 2)
Vasospasm, Intracranial (Phase 4)
Visual Acuity (Phase 3)
Trial | Phase | Start Date | Organizations | Indications |
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