Title
Insulin Resistance Study
The Prevalence of Insulin Resistance and the Potential Modulation of Insulin Resistance by N-acetylcysteine (NAC) in Patients Chronically Infected by the Hepatitis C Virus
Phase
N/ALead Sponsor
Midwest Biomedical Research FoundationStudy Type
InterventionalStatus
SuspendedIndication/Condition
Insulin Resistance Metabolic Syndrome xIntervention/Treatment
acetylcysteine ...Study Participants
121The purpose of this study is to evaluate how often patients with hepatitis C infection have abnormalities of sugar and fat utilization. Additionally we would like to find out if these abnormalities of sugar and fat utilization are common in other liver diseases, or related to being overweight.
N-acetylcysteine 20% 4ml
N-acetylcysteine 20% in 4 ml
One half of the patients will take not medication for 30 days and then have labs redrawn
one half of the patients with insulin resistance will take 4ml of 20% N-acetylcysteine BID for 30 days
Inclusion Criteria: Ability to give written consent HCV RNA PCR positive for 6 months Normal Hgb, WBC,Neutrophils Platelets of >/= 65,000 Direct Bili, within 20% ULN Albumin >3 Serum Creatinine <20% ULN TSH WNL AFP </= 100 Exclusion Criteria: Women who are pregnant or breast-feeding No Thiazolidinedione, Metformin,unless required for the treatment of type II DM Hepatitis C of non-genotype 1,2,3 Any other cause for liver disease other than chronic hepatitis C Hemoglobinopathies Evidence of advanced liver disease Previous organ transplant Severe psychiatric disorder Significant cardiovascular dysfunction within the past 12 months Poorly controlled diabetes mellitus Immunologically mediated disease Any medical condition requiring chronic systemic administration of steroids Evidence of an active or suspected cancer Substance abuse at the time of the study Known HIV Irritability or unwillingness to provide informed consent
