Active Ingredient History
Acetylcysteine (also known as N-acetylcysteine or N-acetyl-L-cysteine or NAC) is primarily used as a mucolytic agent and in the management of acetaminophen poisoning. Acetylcysteine likely protects the liver by maintaining or restoring the glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite. Nacystelyn (NAL), a recently-developed lysine salt of N-acetylcysteine (NAC) is known to have excellent mucolytic capabilities and is used to treat cystic fibrosis (CF) lung disease. NAC as a precursor to the antioxidant glutathione modulates glutamatergic, neurotrophic, and inflammatory pathways. The potential applications of NAC to facilitate recovery after traumatic brain injury, cerebral ischemia, and in treatment of cerebrovascular vasospasm after subarachnoid hemorrhage. Acetylcysteine serves as a prodrug to L-cysteine, which is a precursor to the biologic antioxidant, glutathione, and hence administration of acetylcysteine replenishes glutathione stores. L-cysteine also serves as a precursor to cystine, which in turn serves as a substrate for the cystine-glutamate antiporter on astrocytes hence increasing glutamate release into the extracellular space. Acetylcysteine also possesses some anti-inflammatory effects possibly via inhibiting NF-κB through redox activation of the nuclear factor kappa kinases thereby modulating cytokine synthesis. NAC is associated with reduced levels of inflammatory cytokines and acts as a substrate for glutathione synthesis. These actions are believed to converge upon mechanisms promoting cell survival and growth factor synthesis, leading to increased neurite sprouting. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Acetaminophen (Phase 3)
Acetylcysteine (Phase 2/Phase 3)
Acute Coronary Syndrome (Phase 3)
Acute Febrile Encephalopathy (Phase 2)
Acute Kidney Injury (Phase 4)
Acute Lung Injury (Phase 2)
Adenocarcinoma, Mucinous (Phase 1/Phase 2)
Adipose Tissue (Phase 4)
Adrenoleukodystrophy (Phase 2)
Affective Disorders, Psychotic (Phase 4)
Aging (Phase 1/Phase 2)
Albinism, Oculocutaneous (Phase 1/Phase 2)
Alcohol Drinking (Phase 2)
Alcohol-Induced Disorders (Phase 4)
Alcoholism (Phase 4)
Allografts (Phase 4)
Alopecia (Phase 4)
alpha-Mannosidosis (Phase 2)
Altitude Sickness (Phase 4)
Alzheimer Disease (Early Phase 1)
Analgesics, Opioid (Phase 4)
Anemia (Phase 4)
Anemia, Sickle Cell (Phase 3)
Anesthesia, General (Phase 1)
Angina, Stable (Phase 3)
Anosmia (Phase 3)
Arrhythmias, Cardiac (Phase 2)
Arthroplasty, Replacement, Knee (Phase 4)
Aspartylglucosaminuria (Phase 2)
Asperger Syndrome (Phase 2)
Asthma (Phase 4)
Atherosclerosis (Phase 4)
Atrial Fibrillation (Phase 3)
Autism Spectrum Disorder (Phase 4)
Autistic Disorder (Phase 4)
Bacterial Infections (Phase 4)
Behavior, Addictive (Phase 2)
beta-Thalassemia (Phase 1)
Biliary Atresia (Phase 2)
Biopsy (Phase 1)
Bipolar Disorder (Phase 4)
Blood (Early Phase 1)
Blood Platelet Disorders (Phase 2/Phase 3)
Blood Pressure (Phase 4)
Bone Marrow Diseases (Phase 1)
Borderline Personality Disorder (Phase 2)
Brain Death (Phase 3)
Brain Injuries (Phase 1/Phase 2)
Brain Injuries, Traumatic (Phase 2)
Brain Neoplasms (Phase 1)
Breast Diseases (Phase 4)
Breast Neoplasms (Phase 1)
Bronchiolitis (Phase 4)
Bronchitis, Chronic (Phase 4)
Bulimia Nervosa (Phase 3)
Calcium Hydroxide (Early Phase 1)
Cannabis (Phase 4)
Carcinoma, Bronchogenic (Phase 2)
Carcinoma, Hepatocellular (Phase 2)
Carcinoma, Ovarian Epithelial (Phase 1)
Cardiac Surgical Procedures (Phase 2)
Cardiomyopathy, Hypertrophic (Phase 1)
Cardiopulmonary Bypass (Phase 4)
Cardiovascular Diseases (Phase 4)
Carpal Tunnel Syndrome (Phase 4)
Catheter-Related Infections (Phase 3)
Catheters (Phase 3)
Cerebrospinal Fluid (Phase 1)
Cerebrospinal Fluid Otorrhea (Phase 4)
Child Development Disorders, Pervasive (Phase 2)
Chorioamnionitis (Phase 1/Phase 2)
Cocaine-Related Disorders (Phase 4)
Cognition Disorders (Phase 4)
Cognitive Dysfunction (Phase 1/Phase 2)
Common Cold (Phase 3)
Conjunctivitis (Phase 1)
Connective Tissue Diseases (Phase 2/Phase 3)
Contrast Media (Phase 4)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 4)
Coronavirus Infections (Phase 4)
COVID-19 (Phase 4)
Craniocerebral Trauma (Phase 3)
Critical Illness (Phase 2/Phase 3)
Cystine (Early Phase 1)
Cystinosis (Phase 4)
Deafness (Phase 2/Phase 3)
Deficiency Diseases (Phase 2)
De Lange Syndrome (Phase 2)
Delivery, Obstetric (Phase 2/Phase 3)
Depression (Phase 2)
Depressive Disorder, Major (Early Phase 1)
Dermatology (Phase 2)
Diabetes Mellitus (Phase 3)
Diabetes Mellitus, Type 1 (Phase 1/Phase 2)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Foot (Phase 3)
Diabetic Nephropathies (Phase 2/Phase 3)
Diabetic Neuropathies (Phase 4)
Diabetic Retinopathy (Phase 1)
Dietary Supplements (Phase 4)
DNA Damage (Phase 1/Phase 2)
Drug Delivery Systems (Early Phase 1)
Drug Overdose (Phase 4)
Drug Resistant Epilepsy (Phase 2)
Dry Eye Syndromes (Phase 2)
Endocrine System Diseases (Phase 1/Phase 2)
Endodontics (Early Phase 1)
Endometriosis (Phase 3)
Endothelial Cells (Phase 1/Phase 2)
Erythrocytes, Abnormal (Phase 1)
Euthyroid Sick Syndromes (Phase 4)
Exercise (Phase 4)
Fallopian Tube Neoplasms (Phase 2)
Fatigue (Phase 2)
Fatigue Syndrome, Chronic (Phase 2)
Fatty Liver (Phase 3)
Feeding and Eating Disorders (Early Phase 1)
Fibromyalgia (Phase 1/Phase 2)
Fractures, Bone (Phase 4)
Fuchs' Endothelial Dystrophy (Phase 2)
Fucosidosis (Phase 2)
Gambling (Phase 2)
Gastrointestinal Neoplasms (Phase 2)
Gaucher Disease (Phase 2)
General Surgery (Phase 4)
Genetic Diseases, Inborn (Phase 2)
Glaucoma, Open-Angle (Phase 1)
Glioma (Phase 1)
Glucosephosphate Dehydrogenase Deficiency (Early Phase 1)
Graft vs Host Disease (Phase 3)
Hair (Phase 2)
Hamartoma (Phase 2)
Hand Injuries (Phase 4)
Head and Neck Neoplasms (Phase 4)
Healthy Volunteers (Phase 1)
Hearing Loss (Phase 4)
Hearing Loss, Noise-Induced (Phase 1)
Hearing Loss, Sensorineural (Phase 2/Phase 3)
Heart Defects, Congenital (Phase 2)
Heart Diseases (Phase 3)
Heart Failure (Phase 2/Phase 3)
Heart Valve Diseases (Phase 4)
Helicobacter pylori (Phase 4)
Hematologic Diseases (Phase 3)
Hematopoietic Stem Cell Transplantation (Phase 3)
Hepatectomy (Phase 4)
Hepatic Encephalopathy (Phase 3)
Hepatitis (Phase 2/Phase 3)
Hepatitis, Alcoholic (Phase 4)
Hermanski-Pudlak Syndrome (Phase 1/Phase 2)
HIV (Phase 1/Phase 2)
HIV Infections (Phase 1)
Hodgkin Disease (Phase 2)
Homocystinuria (Phase 2)
Huntington Disease (Phase 2)
Hypertension (Phase 4)
Hypoglycemia (Phase 1/Phase 2)
Hypotension (Phase 2)
Hypoxia (Phase 4)
Hysterectomy (Phase 3)
Idiopathic Pulmonary Fibrosis (Phase 3)
Infant, Premature (Phase 4)
Infections (Phase 3)
Infertility (Phase 3)
Infertility, Female (Phase 3)
Infertility, Male (Phase 1/Phase 2)
Inflammation (Phase 4)
Influenza, Human (Phase 4)
Iron Metabolism Disorders (Phase 2/Phase 3)
Irritable Bowel Syndrome (Phase 1/Phase 2)
Ischemic Stroke (Phase 2)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 4)
Kidney Transplantation (Phase 3)
Learning Disabilities (Phase 4)
Leiomyoma (Phase 2/Phase 3)
Leukemia (Phase 2)
Leukemia, Myeloid, Acute (Phase 2)
Leukodystrophy, Globoid Cell (Phase 2)
Leukodystrophy, Metachromatic (Phase 2)
Liver Diseases (Phase 2)
Liver Failure (Phase 2)
Liver Failure, Acute (Phase 4)
Liver Neoplasms (Phase 2)
Liver Transplantation (Phase 3)
Lung Diseases (Phase 4)
Lung Diseases, Interstitial (Phase 2/Phase 3)
Lung Diseases, Obstructive (Phase 4)
Lung Neoplasms (Phase 4)
Lupus Erythematosus, Systemic (Phase 1/Phase 2)
Lymphoma (Phase 1)
Lymphoma, Non-Hodgkin (Phase 2)
Macular Degeneration (Phase 3)
Marijuana Abuse (Phase 4)
Melanoma (Phase 2)
Metabolic Diseases (Phase 2)
Metabolic Syndrome (Phase 4)
Methamphetamine (Phase 2/Phase 3)
Migraine Disorders (Phase 3)
Mitochondrial Diseases (Phase 1)
Mood Disorders (Phase 4)
Mouth Diseases (Phase 2)
Mucopolysaccharidoses (Phase 2)
Mucopolysaccharidosis I (Phase 2)
Mucopolysaccharidosis II (Phase 2)
Mucopolysaccharidosis VI (Phase 2)
Mucopolysaccharidosis VII (Phase 2)
Mucositis (Phase 3)
Mucus (Phase 3)
Multiple Sclerosis (Phase 2)
Multiple Sclerosis, Chronic Progressive (Phase 2)
Muscle Weakness (Phase 1)
Musculoskeletal Diseases (Phase 2/Phase 3)
Mutation (Phase 2)
Myeloproliferative Disorders (Phase 1/Phase 2)
Myocardial Infarction (Phase 4)
Myocardial Ischemia (Phase 4)
Nail Biting (Phase 3)
Nasal Obstruction (Phase 4)
Neoplasms (Phase 1/Phase 2)
Nerve Fibers (Phase 4)
Neuralgia (Phase 2)
Neuroectodermal Tumors, Primitive (Phase 1)
Neurofibromatosis 1 (Phase 2)
Neuromuscular Diseases (Phase 1/Phase 2)
Niemann-Pick Disease, Type C (Phase 1/Phase 2)
Non-alcoholic Fatty Liver Disease (Phase 2)
Obesity (Phase 2)
Obsessive-Compulsive Disorder (Phase 2)
Obstetric Labor, Premature (Phase 1/Phase 2)
Olfaction Disorders (Phase 3)
Opioid-Related Disorders (Early Phase 1)
Optic Atrophy (Phase 2/Phase 3)
Oral Ulcer (Phase 2)
Organ Transplantation (Phase 3)
Osteoarthritis, Knee (Phase 4)
Osteopetrosis (Phase 2)
Osteosarcoma (Phase 1)
Otitis Media (Phase 4)
Otosclerosis (Phase 4)
Ototoxicity (Phase 4)
Ovarian Neoplasms (Phase 2)
Oxidative Stress (Phase 4)
Oxygen (Phase 4)
Pain, Postoperative (Phase 4)
Pancreatic Neoplasms (Phase 4)
Pancreatitis (Phase 4)
Paranasal Sinus Diseases (Phase 2)
Parkinson Disease (Phase 2)
Peptic Ulcer (Phase 2/Phase 3)
Peripheral Arterial Disease (Phase 1)
Peritoneal Dialysis (Phase 4)
Peroxisomal Disorders (Phase 2)
Persian Gulf Syndrome (Phase 2)
Platelet Storage Pool Deficiency (Phase 1/Phase 2)
Pneumonia, Ventilator-Associated (Phase 1/Phase 2)
Poisoning (Phase 4)
Polycystic Ovary Syndrome (Phase 4)
Polycythemia (Phase 1/Phase 2)
Polycythemia Vera (Phase 1/Phase 2)
Postoperative Complications (Phase 4)
Primary Myelofibrosis (Phase 1/Phase 2)
Proteinuria (Phase 2)
Pruritus (Early Phase 1)
Pseudomyxoma Peritonei (Phase 1/Phase 2)
Psoriasis (Phase 3)
Psychiatry (Phase 2)
Psychomotor Performance (Phase 2)
Psychotic Disorders (Phase 4)
Pulmonary Atelectasis (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Pulmonary Embolism (Phase 4)
Pulmonary Fibrosis (Phase 3)
Purpura, Thrombocytopenic (Early Phase 1)
Purpura, Thrombocytopenic, Idiopathic (Phase 2)
Purpura, Thrombotic Thrombocytopenic (Early Phase 1)
Pyelonephritis (Phase 2)
Quality of Life (Phase 4)
Recurrence (Phase 3)
Refsum Disease, Infantile (Phase 2)
Renal Artery Obstruction (Phase 4)
Renal Insufficiency (Phase 4)
Renal Insufficiency, Chronic (Phase 4)
Reperfusion Injury (Phase 4)
Respiratory Distress Syndrome (Early Phase 1)
Respiratory Tract Diseases (Phase 3)
Respiratory Tract Infections (Phase 1)
Retinitis Pigmentosa (Phase 3)
Rhabdomyolysis (Phase 2)
Rhinitis, Allergic (Phase 1)
Schizophrenia (Phase 4)
Scleroderma, Diffuse (Phase 2/Phase 3)
Self-Injurious Behavior (Phase 2)
Severe Acute Respiratory Syndrome (Phase 1)
Shock, Septic (Phase 3)
Sinusitis (Phase 3)
Skin Diseases (Early Phase 1)
Smoking (Phase 2)
Sphingolipidoses (Phase 2)
Sphingomyelins (Phase 2)
Splints (Phase 4)
ST Elevation Myocardial Infarction (Phase 3)
Stomach Diseases (Phase 4)
Stomach Neoplasms (Phase 4)
Stomatitis (Phase 3)
Stress Disorders, Post-Traumatic (Phase 2)
Substance Abuse, Oral (Phase 2)
Substance-Related Disorders (Phase 4)
Suicide (Phase 2)
Systemic Inflammatory Response Syndrome (Phase 4)
Thoracic Surgery (Phase 3)
Thrombocythemia, Essential (Phase 1/Phase 2)
Thrombocytopenia (Phase 2/Phase 3)
Thrombotic Microangiopathies (Phase 3)
Tics (Phase 2)
Tinnitus (Phase 4)
Tobacco Smoking (Phase 3)
Tobacco Use Disorder (Phase 4)
Tourette Syndrome (Phase 2)
Transposition of Great Vessels (Phase 2)
Trichotillomania (Phase 2)
Tuberculosis (Phase 4)
Tuberculosis, Pulmonary (Phase 2)
Vaginosis, Bacterial (Phase 4)
Vagus Nerve Stimulation (Early Phase 1)
Vascular Grafting (Phase 3)
Ventilation (Phase 4)
Weight Loss (Phase 2)
Zellweger Syndrome (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
Feedback
Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).
Report issue
