Trial | NCT00563862  Report issue

Title

Benefit of Adding Chemotherapy And/Or Modification of Radiotherapy Schedule for Advance Nasopharyngeal Carcinoma (T3-4N0-1M0)
Prospective Randomized Study on Therapeutic Gain Achieved By Chemoradiation And/Or Accelerated Radiation For T3-4N0-1M0 Nasopharyngeal Carcinoma

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Terminated

  • Intervention/Treatment

    fluorouracil cisplatin ...

  • Study Participants

    465
To test the therapeutic ratio of accelerated radiotherapy and/or chemotherapy on locally advanced nasopharyngeal carcinoma.
Study Started
Jul 31
1999
Study Completion
Jun 30
2007
Last Update
Jun 16
2011
Estimate

Procedure Conventional RT

Procedure Accelerated RT

Drug Cisplatin

Drug 5-fluorouracil

Criteria 

Inclusion Criteria:

Undifferentiated or non-keratinizing carcinoma
Tumor staged as T3-4 AND N0-1
No evidence of distant metastasis (M0)
Performance status: 0-2
Marrow: WBC >= 4 and platelet = 100
Renal: creatinine clearance = 60
Informed consent

Exclusion Criteria:

WHO type I squamous cell carcinoma or adenocarcinoma
Age >= 70
Palliative intent or tumor extent mandating AP opposing facio-cervical fields
Prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for 5 years
Previous radiotherapy (except non-melanomatous skin cancers outside the intended RT treatment volume
Previous chemotherapy
Patient is pregnant or lactating
No Results Posted