Trial | NCT00451360  Report issue

Title

Chondromodulating Effect of Diacerein in Osteoarthritis of the Hip
Evaluation of the CHOndromodulating Effect of DIAcerein in Osteoarthritis of the Hip. ECHODIAH.

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    diacerein ...

  • Study Participants

    500
We carried out a 3 years, randomized, double-blind, placebo-controlled, multicenter clinical trial in patients with hip osteoarthritis in order to:

evaluate the ability of diacerein, an interleukin-1β inhibitor, to slow the progressive decrease in joint space width observed in patients with hip osteoarthritis
to investigate the potential structure-modifying effect of diacerein in patients with hip osteoarthritis

This study compare also after ten years the percentage of patients in each treatment group who require a hip replacement surgery
Study Started
Mar 31
1993
Study Completion
Apr 30
1997
Last Update
Jul 25
2008
Estimate

Drug diacerein

Criteria 

Inclusion Criteria:

Outpatients fulfilling the American College of Rheumatology criteria for the diagnosis of hip osteoarthritis.
Lequesne algofunctional index of at list 3 points.
Radiographic criterion for inclusion: joint space width (JSW) between 1 mm and 3 mm. If the JSW exceeded 3 mm, it had to be at least 0.5 mm thinner than JSW of the contra lateral hip, measured at its narrowest point.

Exclusion Criteria:

Intraarticular injection or arthroscopy of the hip during the three months prior to inclusion in the study.
Any systemic or intraarticular corticosteroid as well as other potential symptom-modifying drugs for osteoarthritis were not allowed during the study.
No Results Posted