diacerein Report issue

Small molecule Experimental
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Diacerein (INN), also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis. It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial effect on pain. Diacerein-containing medications are registered in some European Union and Asian countries and included as a treatment option on several international therapeutic guidelines.   Wikipedia

Chemistry

  • SMILES: CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(=O)C)c3C(=O)c12)C(=O)O
  • InChIKey: TYNLGDBUJLVSMA-UHFFFAOYSA-N
  • Mol. Mass: 368.3
  • ALogP: 2.01
  • ChEMBL Molecule:
    diacerein  
More Chemistry

Pharmacology

Alternative names

2-anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo- | art 50 | art brand of diacetylrhein | artrodar | diacerein | diacerhein | diacetylrhein | diacetyl-rhein | fisiodar | negma brand of diacetylrhein | niverpharm brand of diacetylrhein | zondar

Organizations (30)

Research & Development (30)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (22)

Approved Indications (1)


 

Osteoarthritis

Experimental Indications - Clinical Trial Phases 1-4 (22)


 

Arthritis, Rheumatoid (Phase 2)

COVID-19 (Phase 2)

Diabetes Complications (Phase 2)

Diabetes Mellitus (Phase 2)

Diabetes Mellitus, Type 2 (Phase 3)

Drugs, Investigational (Phase 4)

Epidermolysis Bullosa (Phase 2)

Epidermolysis Bullosa Dystrophica (Phase 1)

Epidermolysis Bullosa, Junctional (Phase 1)

Epidermolysis Bullosa Simplex (Phase 2)

Glucosamine (Phase 4)

Gout (Phase 4)

Healthy Volunteers (Phase 1)

Insulin Resistance (Phase 2)

Non-alcoholic Fatty Liver Disease (Phase 3)

Obesity (Phase 2)

Osteoarthritis (Phase 4)

Osteoarthritis, Hip (Phase 3)

Osteoarthritis, Knee (Phase 4)

Overweight (Phase 2)

Pemphigoid, Bullous (Phase 2)

Thrombocytopenia (Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 31
  • # of Trial Organizations: 30

Trials by Phase

Trial Phase Start Date Organizations Indications

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