Title
Efficacy of Pregabalin in Migraine Prevention
Phase
Phase 3Lead Sponsor
Hospital Militar del General Luis Felipe Brieba AranStudy Type
InterventionalStatus
WithdrawnIndication/Condition
Migraine DisordersIntervention/Treatment
valproic acid pregabalin ...Study Participants
70The purpose of this study is to evaluate the efficacy and safety of pregabalin in comparison with sodium valproate in migraine prevention with a randomized blinded crossover study.
The anticonvulsants are effective in the treatment of migraine prevention. The sodium valproate has demonstrated to be effective as monotherapy for migraine prevention in placebo-controlled trials. Besides, other new drugs like gabapentin have been used in the prevention of migraine with a good level of evidence. The pregabalin is an anticonvulsant that has not been proved to use in migraine prevention and it has a similar action mechanisms of the gabapentin. The purpose of this study is the comparison of the effect of pregabalin and sodium valproate in migraine prevention in a randomized blinded crossover study.
Inclusion Criteria: Migraine with or without aura according to International Headache Society (IHS) criteria for at least 6 months before study entry. Frequency of 3 or more headache attacks per month and less than 15 headache attacks per month. Available for follow-up at least 9 months. Exclusion criteria: Patients with headache others than migraine. Patients failed to respond to more than 2 adequate previous regimen of migraine-preventive medications. Prophylactic drugs for migraine 12 weeks before randomization. Onset of migraine occurred after 50 years. Hypersensitivity to pregabalin or sodium valproate.