Active Ingredient History

NOW
  • Now
Valproic acid (VPA; valproate; di-n-propylacetic acid, DPA; 2-propylpentanoic acid, or 2-propylvaleric acid) was first synthesized in 1882, by Burton. FDA approved valproic acid for the treatment of manic episodes associated with bipolar disorder, for the monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures and adjunctive therapy in patients with multiple seizure types that include absence seizures and for the prophylaxis of migraine headaches. The mechanisms of VPA which seem to be of clinical importance in the treatment of epilepsy include increased gamma-aminobutyric acid (GABA)-ergic activity, reduction in excitatory neurotransmission, and modification of monoamines. Recently, it was discovered that the VPA is a class I selective histone deacetylase inhibitor. This activity can be distinguished from its therapeutically exploited antiepileptic activity.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

Australia

$0.0455 - $10.8387

United States

$0.0559 - $2.7510
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

2-n-propyl-n-valeric acid | 2-propyl-pentanoic acid | 2-propylpentanoic acid | 2-propylvaleric acid | 44089 | 4-heptanecarboxylic acid | a-44090 | abbott 44090 | abbott-44090 | abbott-50711 | acide valproïque | ácido valproico | acidum valproicum | convulex | delepsine | depacon | depakene | depakine | depakote | depakote cp | depakote er | di-n-propylacetic acid | di-n-propylessigsäure | dipropylacetic acid | divalproate sodium | divalproex | divalproex | divalproex disodium | divalproex sodium | divaproex | dpa | epilim | epilim 200 | epilim 500 | epilim chrono 200 | epilim chrono 300 | epilim chrono 500 | epilim chronosphere | epilim iv | episenta | epival | kentilim | magnesium valproate | n-dpa | orfiril | orlept | propylisopropylacetic acid | semisodium valproate | sodium divalproate | sodium valproate | stavzor | valdisoval | valproate | valproate calcium | valproate semisodium | valproate sodium | valproic acid | valproic aicd | valproinsäure | vaproate | vpa

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