Trial | NCT00355966  Report issue

Title

Comparison of Misoprostol and PGE2 Gel for Induction of Labour in Women With Premature Rupture of Membranes at Term
Comparison of Misorostol & PGE2 Gel for Immediate Induction of Labour for Premature Ropture of Membranes at Term

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    212
Induction of labour with vaginal misoprostol, in women with premature rupture of membranes at term, results in significant shortening of induction to delivery time in comparison to vaginal PGE2 gel induction.
Study Started
Aug 31
2006
Primary Completion
Sep 30
2008
Study Completion
Sep 30
2008
Last Update
Mar 25
2010
Estimate

Drug Misoprostol

In one group of women immediate induction of labour will be done by intravaginal misoprostol 25 microgram 4 hourly , a maximum of 5 doses .

Drug PGE2 gel

In other group immediate induction of labour will be done by intravaginal application of PGE2 gel 0.5 mg at an interval of 6 hours , a maximum of 2 doses.

A Active Comparator

In group A, immediate induction of labour will be done by intravaginal misoprostol 25 microgram 4 hourly , a maximum of 5 doses .

B Active Comparator

In Group B immediate induction of labour will be done by application of vaginal PGE2 gel 0.5 gm at an interval of 6 hours , a maximum of 2 doses.

Criteria 

Inclusion Criteria:

Premature rupture of membranes at 37 or more weeks
Single live fetus in cephalic presentation

Exclusion Criteria:

Women in labour
Women with contraindication of induction of labour
Women with previous caesarean section or uterine surgery
No Results Posted