Trial | NCT00355303  Report issue

Title

Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term
Comparison of Misoprostol and PGE2 Gel for Induction of Labour in in Premature Rupture of Membranes at Term- A Randomized Comparative Trial

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    932
The purpose of this study is to determine whether induction of labor with vaginal misoprostol application will result in fewer cesarean deliveries than vaginal PGE2 gel application in women with premature rupture of membranes at term.
Study Started
Aug 31
2006
Primary Completion
May 31
2013
Study Completion
May 31
2013
Last Update
Jul 22
2015
Estimate

Drug Misoprostol

Vaginal application of Misoprostol tablets at 4 hrly interval with maximumof five doses

  • Other names: Misoprost

Drug PGE2 gel

PGE2 gel will be applied in poaterior fornix at six hrly interval with maximum of 2 doses

  • Other names: Dinoprostone gel

Misoprostol tablet, PGE2 gel Active Comparator

participants are assigned to one of two arms for the duration of the study In one group induction of labour is done by intravaginal misoprostol tablets at 4 hrly interval with maximum of five doses.In other group PGE2 gel is applied in poaterior fornix at six hourly interval.

Criteria 

Inclusion Criteria:

Premature rupture of membranes at 37 or more weeks
Single live fetus in cephalic presentation

Exclusion Criteria:

Women in labour
Women with contraindication of induction of labour
Women with previous caesarean section or uterine surgery
No Results Posted