Title
The New Strategy for Pharmacological Treatment in People With Schizophrenia
Switch Risperidone to Aripiprazole in Early Stage of Pharmacotherapy of Schizophrenia
Phase
Phase 4Lead Sponsor
Inje UniversityStudy Type
InterventionalStatus
Unknown statusIndication/Condition
SchizophreniaIntervention/Treatment
risperidone aripiprazole ...Study Participants
90Switching from Risperidone to Aripiprazole in early stage of pharmacotherapy will demonstrate the same efficacy as compared to risperidone continuation treatment in the treatment of schizophrenia.
It has been thought that D2 Blocking agent is necessary in acute as well as maintenance phase of pharmacological treatment of patients with schizophrenia. However, this classical strategy produces long term adverse events of drug such as TD, osteoporosis and some metabolic syndrome. To overcome these adverse events, new strategy for pharmacological treatment is needed.
Start with risperidone and switch it to aripiprazole. Flexible dose
Start with risperidne and keep it through the end of study. Risperidne:flexible dose
Start with abilify and keep it through the end of study
switching group (from risperidone to aripiprazole)
Start with risperidone and keep it through the end of study
Inclusion Criteria: Schizophrenia, DSM-IV Acute phase Exclusion Criteria: Refractory Schizophrenia Substance Abuse High risk for suicide