Trial | NCT00338091  Report issue

Title

Long-Term Renoprotection of Optimal Antiproteinuric Doses of Benazepril and Losartan in Chronic Renal Insufficiency

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Terminated

  • Study Participants

    None
The primary goal of the trial was to evaluate whether the optimal antiproteinuric doses of benazepril (an ACE inhibitor) or losartan (an ARB), as compared with their conventional doses, can safely improve the long-term renal outcome in nondiabetic patients with proteinuria and chronic renal insufficiency. The second aim was to compare the long-term renal protection between benazepril and losartan at similar clinical setting.
Study Started
Jan 31
2002
Study Completion
May 31
2006
Last Update
Jun 20
2006
Estimate

Drug Benazepril

Drug Losartan

Criteria 

Inclusion Criteria:

Serum creatinine concentration of 1.5 to 5.0 mg per deciliter (133 to 442 µmol/L)
Creatinine clearance of 20 to 70 ml per minute per 1.73m2, with variations of less than 30 percent in the three months before screening evaluation
nondiabetic renal disease
Persistent heavier proteinuria (defined by urinary protein excretion of more than 1.0 g per day for three or more months without evidence of urinary tract infection or overt heart failure [a New York Heart Association class of Ⅲ or Ⅳ])

Exclusion Criteria:

Immediate need for dialysis
Treatment with corticosteroids, non steroidal anti-inflammatory drugs, or immunosuppressive drugs
Hyper-or hypokalemia (serum potassium concentration 5.6 mmol per liter or more，or 3.5 mmol per liter or less)
Renovascular disease
Myocardial infarction or cerebrovascular accident in the year preceding the trial
Connective-tissue disease; and obstructive uropathy
No Results Posted