Trial | NCT00292708  Report issue

Title

Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery
Randomized Multicenter Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery: Single-Dose Vs. Three Doses of Second-Generation Cephalosporin

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    cefmetazole ...

  • Study Participants

    500
To determine the optimal prophylactic antibiotics administration method in elective colorectal surgery
Use of prophylactic antibiotics in elective colorectal surgery is essential. Although single-dose prophylactic antibiotics are recommended, the efficacy of single-dose cephalosporin without metronidazole and oral antibiotics is not fully proven. We conducted a multicenter randomized trial of single-dose vs. three doses of the second-generation cephalosporin, cefmetazole.
Study Started
May 31
2004
Study Completion
Jul 31
2005
Last Update
Feb 16
2006
Estimate

Drug Cefmetazole (drug)

Criteria 

Inclusion Criteria:

Colorectal diseases (cancer, large polyp, carcinoid, lymphoma,sarcoma and so on)
Elective colorectal resection

Exclusion Criteria:

Emergent operation
Ileus
No resection
Preoperative infectious diseases
Penicillin or cephalosporin allergy
Antibiotics administration before surgery
Inflammatory bowel diseases
Angina or myocardial infarction
Renal dysfunction
Diabetes mellitus
Steroid administration before surgery
No Results Posted