cefmetazole (zefazone) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Cefmetazole is a semisynthetic cephamycin antibiotic. It has a broad spectrum of activity comparable to that of the second-generation cephalosporins, covering gram-positive, gram-negative, and anaerobic bacteria. Its bactericidal action results from inhibition of cell wall synthesis. It effectively treats abdominal and respiratory tract infections, pelvic inflammatory disease, urinary tract infections, skin and soft tissue infections and used for surgical prophylaxis, reducing or eliminating signs and symptoms of infection. Cefmetazole has a low frequency of adverse effects, and a side effect profile similar to that of other cephamycins. Adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.   NCATS

Chemistry

  • SMILES: CO[C@@]1(NC(=O)CSCC#N)C(=O)N2C(C(=O)O)=C(CSc3nnnn3C)CS[C@@H]21
  • InChIKey: SNBUBQHDYVFSQF-HIFRSBDPSA-N
  • Mol. Mass: 471.55
  • ALogP: -0.73
  • ChEMBL Molecules:
    cefmetazole  
    cefmetazole sodium  
More Chemistry

Pharmacology

Alternative names

(6r,7s)-7-({[(cyanomethyl)sulfanyl]acetyl}amino)-7-methoxy-3-{[(1-methyl-1h-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | cefmetazole | cefmetazole sodium | cefmetazole sodium salt | cefmetazolo | cefmetazolum | u-72791 | u-72791a | zefazone

Organizations (5)

Research & Development (4)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (8)

Approved Indications (5)


 

Genital Diseases, Female

Intraabdominal Infections

Respiratory Tract Infections

Staphylococcal Skin Infections

Urinary Tract Infections

Experimental Indications - Clinical Trial Phases 1-4 (3)


 

Colorectal Neoplasms (Phase 3)

Colorectal Surgery (Phase 3)

Femoral Neck Fractures (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 3
  • # of Trial Organizations: 4

Trials by Phase

Trial Phase Start Date Organizations Indications

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